The Relationship Between Type 2 Diabetes, NAFLD, and Cardiovascular Risk

被引：175

作者：

Caussy, Cyrielle ^{[1
]}

Aubin, Adrien ^{[1
]}

Loomba, Rohit ^{[2
,3
,4
]}

机构：

[1] Hosp Civils Lyon, Dept Endocrinol Diabete & Nutr, Hop Lyon Sud, F-69495 Pierre Benite, France

[2] Univ Calif San Diego, Dept Med, NAFLD Res Ctr, La Jolla, CA 92093 USA

[3] Univ Calif San Diego, Dept Med, Div Gastroenterol, La Jolla, CA 92093 USA

[4] Univ Calif San Diego, Dept Family & Prevent Med, Div Epidemiol, La Jolla, CA 92093 USA

来源：

CURRENT DIABETES REPORTS | 2021年 / 21卷 / 05期

关键词：

Nonalcoholic fatty liver disease; Nonalcoholic steatohepatitis; Type; 2; diabetes; Fibrosis; Cirrhosis; Cardiovascular disease; Insulin resistance; Metabolic syndrome; FATTY LIVER-DISEASE; LOW-DENSITY LIPOPROTEINS; CORONARY-ARTERY-DISEASE; ISCHEMIC-HEART-DISEASE; TRIMETHYLAMINE-N-OXIDE; ADVANCED FIBROSIS; GUT MICROBIOME; VASCULAR COMPLICATIONS; INSULIN-RESISTANCE; GLYCEMIC CONTROL;

D O I：

10.1007/s11892-021-01383-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Purpose of Review Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) are strongly associated. Both also associate with an increased risk of cardiovascular disease (CVD). Recent Findings Several studies have provided evidence that NAFLD could be an independent CVD risk factor. Given the strong association between NAFLD and T2DM, assessing the independent CV effect of these two conditions remains challenging. However, patients with T2DM and NAFLD exhibit higher risk of CVD compared with T2DM without NAFLD suggesting a potential synergistic increase of CV risk in patients with both T2DM and NAFLD supported by several shared pathophysiological pathways. Several anti-diabetic therapies have shown beneficial effect on both NAFLD and CVD. Patients with T2DM and NAFLD should be considered at high risk of CVD and could benefit from more intensive CV prevention. Additional long-term follow-up is needed to demonstrate that the treatment of NAFLD effectively reduces the risk of CVD.

引用

页数：13

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