Ras farnesyltransferase: A new therapeutic target

被引：251
作者：
Leonard, DM
机构：
[1] Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, MI 48105
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1997年 / 40卷 / 19期
关键词：
D O I：
10.1021/jm970226l
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
[No abstract available]
引用
收藏
页码：2971 / 2990
页数：20
相关论文
共 185 条
[1]  
Abrams SI, 1996, SEMIN ONCOL, V23, P118
[2]  
ADAMSON P, 1992, J BIOL CHEM, V267, P20033
[3]   CLEAVAGE OF FARNESYLATED COOH-TERMINAL HEPTAPEPTIDE OF MOUSE N-RAS BY BRAIN MICROSOMAL-MEMBRANES - EVIDENCE FOR A CARBOXYPEPTIDASE, WHICH SPECIFICALLY REMOVES THE COOH-TERMINAL METHIONINE [J].
AKOPYAN, TN ;
COUEDEL, Y ;
BEAUMONT, A ;
FOURNIEZALUSKI, MC ;
ROQUES, BP .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 187 (03) :1336-1342
[4]  
ANDEREGG RJ, 1988, J BIOL CHEM, V263, P18236
[5]   CAAX GERANYLGERANYL TRANSFERASE TRANSFERS FARNESYL AS EFFICIENTLY AS GERANYLGERANYL TO RHOB [J].
ARMSTRONG, SA ;
HANNAH, VC ;
GOLDSTEIN, JL ;
BROWN, MS .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (14) :7864-7868
[6]   ENDOPROTEOLYTIC PROCESSING OF A FARNESYLATED PEPTIDE INVITRO [J].
ASHBY, MN ;
KING, DS ;
RINE, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (10) :4613-4617
[7]   RAS GENES [J].
BARBACID, M .
ANNUAL REVIEW OF BIOCHEMISTRY, 1987, 56 :779-827
[8]   INCORPORATION OF A PRODUCT OF MEVALONIC ACID METABOLISM INTO PROTEINS OF CHINESE-HAMSTER OVARY CELL-NUCLEI [J].
BECK, LA ;
HOSICK, TJ ;
SINENSKY, M .
JOURNAL OF CELL BIOLOGY, 1988, 107 (04) :1307-1316
[9]  
Bernhard EJ, 1996, CANCER RES, V56, P1727
[10]   RATIONAL DESIGN OF POTENT CARBOXYLIC-ACID BASED BISUBSTRATE INHIBITORS OF RAS FARNESYL-PROTEIN TRANSFERASE [J].
BHIDE, RS ;
PATEL, DV ;
PATEL, MM ;
ROBINSON, SP ;
HUNIHAN, LW ;
GORDON, EM .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1994, 4 (17) :2107-2112
12345678910