Decoding the Complex Free Radical Cascade by Using a DNA Framework-Based Artificial DNA Encoder

被引：13

作者：

Zhang, Lili ^{[1
]}

Wang, Linlin ^{[1
]}

Yuan, Xi ^{[1
]}

Zhong, Minjuan ^{[1
]}

Chen, Hong ^{[1
]}

Zhang, Dailiang ^{[1
]}

Han, Xiaoyan ^{[1
]}

Xie, Sitao ^{[1
]}

He, Lei ^{[1
]}

Li, Yazhou ^{[1
]}

Chen, Fengming ^{[1
]}

Liu, Yanlan ^{[1
]}

Tan, Weihong ^{[1
,2
,3
]}

机构：

[1] Hunan Univ, Mol Sci & Biomed Lab MBL, State Key Lab Chemo Biosensing & Chemometr, Coll Chem & Chem Engn,Aptamer Engn Ctr Hunan Prov, Changsha 410082, Hunan, Peoples R China

[2] Chinese Acad Sci, Canc Hosp, Univ Chinese Acad Sci, Zhejiang Canc Hosp,Inst Basic Med & Canc IBMC, Hangzhou 310022, Zhejiang, Peoples R China

[3] Fdn Appl Mol Evolut, 13709 Progress Blvd, Alachua, FL 32615 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2021年 / 60卷 / 19期

基金：

中国国家自然科学基金;

关键词：

DNA frameworks; DNA nanotechnology; free radical cascades; molecular communication; obesity;

D O I：

10.1002/anie.202014088

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

DNA-based molecular communications (DMC) are critical for regulating biological networks to maintain stable organismic functions. However, the complicated, time-consuming information transmission process involved in genome-coded DMC and the limited, vulnerable decoding activity generally lead to communication impairment or failure, in response to external stimuli. Herein, we present a conceptually innovative DMC strategy mediated by the DNA framework-based artificial DNA encoder. With the free-radical cascade as a proof-of-concept study, the artificial DNA encoder shows active sensing and real-time actuation, in situ and broad free radical-decoding efficacy, as well as robust resistance to environmental noise. It can also block undesirable short-to-medium-range communications between free radicals and inflammatory networks, leading to a synergistic anti-obesity effect. The artificial DNA encoder-based DMC may be generalized to other communication systems for a variety of applications.

引用

页码：10745 / 10755

页数：11

共 52 条

[51] NADPH oxidases and oxidase crosstalk in cardiovascular diseases: novel therapeutic targets [J].