Maternal immune markers during pregnancy and child neurodevelopmental outcomes at age 20 months in the Seychelles Child Development Study

被引：10

作者：

Irwin, Jessica L. ^{[1
]}

McSorley, Emeir M. ^{[2
]}

Yeates, Alison J. ^{[2
]}

Mulhern, Maria S. ^{[2
]}

Strain, J. J. ^{[2
]}

Watson, Gene E. ^{[1
]}

Grzesik, Katherine ^{[1
]}

Thurston, Sally W. ^{[1
]}

Love, Tanzy M. ^{[1
]}

Smith, Tristram H. ^{[1
]}

Broberg, Karin ^{[3
]}

Shamlaye, Conrad F. ^{[4
]}

Myers, Gary J. ^{[1
]}

Davidson, Philip W. ^{[1
]}

van Wijngaarden, Edwin ^{[1
]}

机构：

[1] Univ Rochester, Sch Med & Dent, 601 Elmwood Ave, Rochester, NY 14642 USA

[2] Ulster Univ, Nutr Innovat Ctr Food & Hlth NICHE, Cromore Rd, Coleraine BT52 1SA, Co Londonderry, North Ireland

[3] Karolinska Inst, Inst Environm Med, Nobels Vag 13, SE-17177 Stockholm, Sweden

[4] Minist Hlth, Box 52, Mahe, Seychelles

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2019年 / 335卷

基金：

美国国家卫生研究院;

关键词：

Inflammatory markers; Developmental outcomes; Children; Pregnancy; AUTISM SPECTRUM DISORDERS; PRENATAL INFECTION; METHYLMERCURY EXPOSURE; BRAIN-DEVELOPMENT; METHYL MERCURY; CYTOKINES; RISK; SCHIZOPHRENIA; DYSFUNCTION; BIOMARKERS;

D O I：

10.1016/j.jneuroim.2019.577023

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune dysregulation during pregnancy may influence behavior and neurodevelopment in offspring, but few human studies have tested this hypothesis. Using structural equation modeling, we examined associations between maternal inflammatory markers at 28 weeks gestation and child neurodevelopmental outcomes at 20 months of age in a sample of 1453 mother-child pairs. We observed several associations between maternal inflammatory markers measured in the late second or early third trimester and child neurodevelopmental outcomes. The direction of association for some markers was unexpected. Further research is warranted to confirm and elucidate the exact nature of these findings.

引用

页数：8

共 34 条

[1] Amniotic fluid inflammatory cytokines: Potential markers of immunologic dysfunction in autism spectrum disorders [J].

Abdallah, Morsi W. ;

Larsen, Nanna ;

Grove, Jakob ;

Norgaard-Pedersen, Bent ;

Thorsen, Poul ;

Mortensen, Erik L. ;

Hougaard, David M. .

WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 2013, 14 (07) :528-538

[2] An immune clock of human pregnancy [J].

Aghaeepour, Nima ;

Ganio, Edward A. ;

Mcilwain, David ;

Tsai, Amy S. ;

Tingle, Martha ;

Van Gassen, Sofie ;

Gaudilliere, Dyani K. ;

Baca, Quentin ;

McNeil, Leslie ;

Okada, Robin ;

Ghaemi, Mohammad S. ;

Furman, David ;

Wong, Ronald J. ;

Winn, Virginia D. ;

Druzin, Maurice L. ;

El-Sayed, Yaser Y. ;

Quaintance, Cecele ;

Gibbs, Ronald ;

Darmstadt, Gary L. ;

Shaw, Gary M. ;

Stevenson, David K. ;

Tibshirani, Robert ;

Nolan, Garry P. ;

Lewis, David B. ;

Angst, Martin S. ;

Gaudilliere, Brice .

SCIENCE IMMUNOLOGY, 2017, 2 (15)

[3] Do children with autism spectrum disorders have motor learning difficulties? [J].

Bo, Jin ;

Lee, Chi-Mei ;

Colbert, Alison ;

Shen, Bo .

RESEARCH IN AUTISM SPECTRUM DISORDERS, 2016, 23 :50-62

[4] Effects of prenatal infection on brain development and behavior: A review of findings from animal models [J].

Boksa, Patricia .

BRAIN BEHAVIOR AND IMMUNITY, 2010, 24 (06) :881-897

[5] Elevated maternal C-reactive protein and autism in a national birth cohort [J].

Brown, A. S. ;

Sourander, A. ;

Hinkka-Yli-Salomaki, S. ;

McKeague, I. W. ;

Sundvall, J. ;

Surcel, H-M .

MOLECULAR PSYCHIATRY, 2014, 19 (02) :259-264

[6] Epidemiologic studies of exposure to prenatal infection and risk of schizophrenia and autism [J].

Brown, Alan S. .

DEVELOPMENTAL NEUROBIOLOGY, 2012, 72 (10) :1272-1276

[7] Cytokines in the perinatal period - Part II [J].

Chau, A. ;

Markley, J. C. ;

Juang, J. ;

Tsen, L. C. .

INTERNATIONAL JOURNAL OF OBSTETRIC ANESTHESIA, 2016, 26 :48-58

[8] Intrauterine infection, cytokines, and brain damage in the preterm newborn [J].

Dammann, O ;

Leviton, A .

PEDIATRIC RESEARCH, 1997, 42 (01) :1-8

[9] Prerequisites for cytokine measurements in clinical trials with multiplex immunoassays [J].

de Jager, Wilco ;

Bourcier, Katarzyna ;

Rijkers, Ger T. ;

Prakken, Berent J. ;

Seyfert-Margolis, Vicki .

BMC IMMUNOLOGY, 2009, 10 :52

[10] The two faces of IL-6 on Th1/Th2 differentiation [J].

Diehl, S ;

Rincón, M .

MOLECULAR IMMUNOLOGY, 2002, 39 (09) :531-536

← 1 2 3 4 →