Implication of cellular senescence in the progression of chronic kidney disease and the treatment potencies

被引：22
作者：
Wang, Yao [1 ]
Wang, Ying [2 ]
Yang, Ming [1 ]
Ma, Xingjie [3 ]
机构：
[1] Yangzhou Univ, Affiliated Hosp, Dept Nephrol, Yangzhou, Jiangsu, Peoples R China
[2] Yangzhou Univ, Affiliated Hosp, Dept Endocrinol, Yangzhou, Jiangsu, Peoples R China
[3] Yangzhou Univ, Affiliated Hosp, Dept Intens Care, Yangzhou, Jiangsu, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2021年 / 135卷
基金：
中国国家自然科学基金;
关键词：
Chronic kidney disease; Cellular senescence; SASP; SCAPs; Senolytics; SECRETORY PHENOTYPE; CAPILLARY RAREFACTION; MITOCHONDRIAL DYSFUNCTION; REGENERATIVE CAPACITY; CALORIC RESTRICTION; AUTOPHAGIC ACTIVITY; OXIDATIVE STRESS; DNA-DAMAGE; AGED RATS; CELLS;
D O I：
10.1016/j.biopha.2020.111191
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Chronic kidney disease (CKD) is an increasing major public health problem worldwide. And CKD shares numerous phenotypic similarities with kidney as well as systemic ageing. Cellular senescence is mainly characterized by a stable cell cycle arrest, senescence-associated secretory phenotype (SASP) and senescent cell antiapoptotic pathways (SCAPs). Herein, the regulations and the internal mechanisms of cellular senescence will be discussed. Meanwhile, efforts are made to give a comprehensive overview of the recent advances of the implication of cellular senescence in CKD. To date, numerous studies have focused on the effects of ageing risk factors in kidney and thereby trying to interrupt the kidney ageing processes with senolytics. Interestingly, some of them showed enormous clinical application potentials. Therefore, senotherapeutics can be applied as novel potential strategies for the treatment of CKD.
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页数：10
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