Metabolic Flexibility in Health and Disease

被引：629
作者：
Goodpaster, Bret H. [1 ]
Sparks, Lauren M. [1 ]
机构：
[1] Florida Hosp, Translat Res Inst Metab & Diabet, Sanford Burnham Prebys Med Discovery Inst, 301 East Princeton St, Orlando, FL 32804 USA
来源：
CELL METABOLISM | 2017年 / 25卷 / 05期
基金：
美国国家卫生研究院;
关键词：
FATTY-ACID-METABOLISM; MUSCLE INSULIN-RESISTANCE; DEPENDENT DIABETES-MELLITUS; SUBCUTANEOUS ADIPOSE-TISSUE; CORONARY-HEART-DISEASE; HUMAN SKELETAL-MUSCLE; WEIGHT-LOSS; IN-VIVO; MITOCHONDRIAL-FUNCTION; ENDURANCE PERFORMANCE;
D O I：
10.1016/j.cmet.2017.04.015
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Metabolic flexibility is the ability to respond or adapt to conditional changes in metabolic demand. This broad concept has been propagated to explain insulin resistance and mechanisms governing fuel selection between glucose and fatty acids, highlighting the metabolic inflexibility of obesity and type 2 diabetes. In parallel, contemporary exercise physiology research has helped to identify potential mechanisms underlying altered fuel metabolism in obesity and diabetes. Advances in "omics'' technologies have further stimulated additional basic and clinical-translational research to further interrogate mechanisms for improved metabolic flexibility in skeletal muscle and adipose tissue with the goal of preventing and treating metabolic disease.
引用
收藏
页码：1027 / 1036
页数：10
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