The Preparation and Application of Dendrimer Modified CdTe/CdS Near Infrared Quantum Dots for Brain Cancer Cells Imaging

被引：9

作者：

Bai, Qingke ^{[1
]}

Zhao, Zhenguo ^{[2
]}

Sui, Haijing ^{[2
]}

Chen, Juan ^{[1
]}

Xie, Xiuhai ^{[2
]}

Wen, Feng ^{[2
]}

机构：

[1] Pudong Peoples Hosp, Dept Neurol, Shanghai 201299, Peoples R China

[2] Pudong Peoples Hosp, Dept Radiol, Shanghai 201299, Peoples R China

来源：

APPLIED SCIENCES-BASEL | 2015年 / 5卷 / 04期

关键词：

noninvasive cancer diagnosis; brain imaging; nanotechnology; near infrared; quantum dots;

D O I：

10.3390/app5041076

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The most notable obstacle of brain cancer diagnosis is the inability of delivering imaging agents across the blood-brain barrier (BBB). Recently, quantum dots (QDs) has been demonstrated as an ideal image agent for brain imaging due to their ultra-small size for crossing BBB. The plolyamidoamine dendrimers modified CdTe/CdS core/shell near-infrared (NIR) region QDs was successfully synthesized in aqueous solution, and then was characterized by UV-vis absorption, photoluminescence (PL) spectroscopy, dynamic light scattering (DLS), X-ray powder diffraction (XRD) and high-resolution transmission electron microscopy (HR-TEM), etc. Our results reveal that the dendrimers modified CdTe/CdS QDs exhibits good water-dispersity and stable NIR fluorescence in various biological environments. In addition, this NIR QDs demonstrates a good biocompatibility and sensitive photoluminescence responses in brain tumor cell imaging. In a word, this type of dendrimers modified NIR CdTe/CdS QDs has huge potential applications in brain imaging.

引用

页码：1076 / 1085

页数：10

共 14 条

[1] Mercury(II) sensing based on the quenching of fluorescence of CdS-dendrimer nanocomposites [J].

Campos, Bruno B. ;

Algarra, Manuel ;

Alonso, Beatriz ;

Casado, Carmen M. ;

Esteves da Silva, Joaquim C. G. .

ANALYST, 2009, 134 (12) :2447-2452

[2]

Chang J. - Y., 2007, NANOTECHNOLOGY, V18

[3] Non-invasive near infrared fluorescence imaging of CdHgTe quantum dots in mouse model [J].

Chen, Haiyan ;

Wang, Yunqing ;

Xu, Jing ;

Ji, Jinzi ;

Zhang, Jian ;

Hu, Yuzhu ;

Gu, Yueqing .

JOURNAL OF FLUORESCENCE, 2008, 18 (05) :801-811

[4]

Cong RM, 2006, CHEM J CHINESE U, V27, P793

[5] Functional near-infrared optical imaging: Utility and limitations in human brain mapping [J].

Hoshi, Y .

PSYCHOPHYSIOLOGY, 2003, 40 (04) :511-520

[6]

Kircher MF, 2003, CANCER RES, V63, P8122

[7] Brain cancer diagnosis and therapy with nanoplatforms [J].

Koo, Yong-Eun Lee ;

Reddy, G. Ramachandra ;

Bhojani, Mahaveer ;

Schneider, Randy ;

Philbert, Martin A. ;

Rehemtulla, Alnawaz ;

Ross, Brian D. ;

Kopelman, Raoul .

ADVANCED DRUG DELIVERY REVIEWS, 2006, 58 (14) :1556-1577

[8] Preparation and bioapplication of high-quality, water-soluble, biocompatible, and near-infrared-emitting CdSeTe alloyed quantum dots [J].

Liang, Guo-Xi ;

Gu, Miao-Miao ;

Zhang, Jian-Rong ;

Zhu, Jun-Jie .

NANOTECHNOLOGY, 2009, 20 (41)

[9] Synthesis of high-quality near-infrared-emitting CdTeS alloyed quantum dots via the hydrothermal method [J].

Mao, Weiyong ;

Guo, Jia ;

Yang, Wuli ;

Wang, Changchun ;

He, Jia ;

Chen, Jiyao .

NANOTECHNOLOGY, 2007, 18 (48)

[10] Synthesis and photoluminescence characterization of dendrimer-encapsulated CdS quantum dots [J].

Yamamoto, Daigo ;

Koshiyama, Tomohiro ;

Watanabe, Satoshi ;

Miyahara, Minoru T. .

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 2012, 411 :12-17

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