Apoptosis in ischemic heart disease

被引：219
作者：
Teringova, Elena [1 ,2 ]
Tousek, Petr [1 ,2 ]
机构：
[1] Charles Univ Prague, Dept Cardiol, Fac Med 3, Cardioctr, Srobarova 50, Prague 10034 10, Czech Republic
[2] Univ Hosp Kralovske Vinohrady, Srobarova 50, Prague 10034 10, Czech Republic
来源：
JOURNAL OF TRANSLATIONAL MEDICINE | 2017年 / 15卷
关键词：
Apoptosis; Ischemic heart disease; Outcome; Heart failure; TUMOR-NECROSIS-FACTOR; ACUTE MYOCARDIAL-INFARCTION; FACTOR-ALPHA THERAPY; SOLUBLE FAS; PROGNOSTIC VALUE; BCL-2; PROTEIN; PLASMA-LEVELS; SERUM-LEVELS; CELL-DEATH; FAILURE;
D O I：
10.1186/s12967-017-1191-y
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Apoptosis plays an important role in the myocardial loss after acute myocardial infarction and participates in the process of subsequent left ventricular remodeling and development of symptomatic heart failure. Finding a sensitive apoptotic marker that would help in prognostic stratification of patients after acute myocardial infarction and offer new therapeutic strategies is thus of a great importance. Several studies suggest that tumor necrosis factor-related apoptosis inducing ligand (TRAIL) represents a very promising marker of prognosis in patients with acute myocardial infarction. This review article provides an overview of current knowledge on the role of apoptosis in ischemic heart disease and highlights potentially beneficial apoptotic markers in clinical practice.
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页数：7
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