Positive BCL2L12 expression predicts favorable prognosis in patients with laryngeal squamous cell carcinoma

被引:15
|
作者
Giotakis, Aris, I [1 ]
Lazaris, Andreas C. [2 ]
Kataki, Agapi [3 ]
Kontos, Christos K. [4 ]
Giotakis, Evangelos, I [1 ]
机构
[1] Natl & Kapodistrian Univ Athens, Med Univ Athens, Hippocrat Hosp, Dept Otorhinolaryngol 1, Vas Sofias 114, Athens 11527, Greece
[2] Natl & Kapodistrian Univ Athens, Med Univ Athens, Dept Pathol, Athens, Greece
[3] Natl & Kapodistrian Univ Athens, Dept Propaedeut Surg 1, Hippocrat Hosp, Med Univ Athens,Lab Surg Res, Athens, Greece
[4] Univ Athens, Dept Biochem & Mol Biol, Athens, Greece
关键词
Laryngeal neoplasms; BCL2L12; biomarkers; prognosis; survival; BCL-2; EXPRESSION; MOLECULAR-CLONING; P53; GENE; CANCER; BAX; OVEREXPRESSION; METASTASIS; MANAGEMENT; VARIANTS;
D O I
10.3233/CBM-181772
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BACKGROUND: Laryngeal squamous cell carcinoma (LSCC) constitutes the third most frequent head and neck cancer. Several tissue biomarkers have been studied for their prognostic significance in LSCC. OBJECTIVE: To investigate the prognostic significance of BCL2L12, a new member of the BCL2 family, in primary LSCC along with well-examined biomarkers such as BCL2 and BAX. METHODS: Cancerous tissue specimens of patients with primary LSCC were collected during 2005 and 2012 as pretreatment tissue biopsy. The specimens were immunohistochemically evaluated for the protein expression of BCL2L12, BCL2 and BAX. Kaplan-Meier survival curves and Cox proportional hazard regression models were performed to evaluate prognosis. RESULTS: In the study cohort of 78 patients with primary LSCC, Kaplan-Meier survival curves demonstrated that advancedstage LSCC patients with BCL2L12-positive tumors had significantly higher OS time in comparison with advanced-stage LSCC patients with BCL2L12-negative tumors (p = 0.014). Also, advanced-stage LSCC patients with BCL2L12-positive tumors had significantly lower risk of death from LSCC compared to advanced-stage LSCC patients with BCL2L12-negative tumors (HR = 0.228, 95% CI = 0.063-0.833, p = 0.025). CONCLUSIONS: BCL2L12 protein expression could be used as a favorable prognostic tissue biomarker in patients with primary advanced-stage LSCC. On the contrary, BCL2 and BAX did not correlate with prognosis in patients with primary LSCC.
引用
收藏
页码:141 / 149
页数:9
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