Multidrug resistant cancer cells susceptibility to cytotoxic taxane Diterpenes from Taxus yunnanensis and Taxus chinensis

被引：14

作者：

Shinozaki, Y

Fukamiya, N ^{[1
]}

Uchiyama, C

Okano, M

Tagahara, K

Bastow, KF

Lee, KH

机构：

[1] Hiroshima Univ, Fac Integrated Arts & Sci, Dept Interdisciplinary Studies Nat Environm, Higashihiroshima 7398521, Japan

[2] Kobe Pharmaceut Univ, Fac Pharmaceut Sci, Kobe, Hyogo 6588558, Japan

[3] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 19期

关键词：

D O I：

10.1016/S0960-894X(02)00528-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Twelve taxane diterpenes (1-12), which were isolated previously from the EtOH extract of the aerial parts of Taxus yunnanensis or Taxus chinensis, were evaluated for cytotoxicity against the multidrug resistant cancer cells KB-VIN and KB-7d. Compounds 10 and 11 showed significant cytotoxicity in these cell lines. Compounds 3 and 12 also demonstrated significant activity against KB-7d. The biflavonoid 13 isolated from T. yunnanensis was only marginally cytotoxic against the A549 (lung) cell line, but a simple methoxylated analogue (14) was inactive. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：2785 / 2788

页数：4

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