Liquid PEG4-PLLA copolymers: Effect of chirality and molecular weight on mechanical properties

被引：5

作者：

Galperin, Leonid ^{[1
]}

Eylon, Bat-hen ^{[1
]}

Mizrahi, Boaz ^{[1
]}

机构：

[1] Technion, Fac Biotechnol & Food Engn, IL-32000 Haifa, Israel

来源：

POLYMERS FOR ADVANCED TECHNOLOGIES | 2022年 / 33卷 / 11期

关键词：

drug release; polyethylene glycol; polylactic acid; star polymer; viscosity; LIPOSOMAL BUPIVACAINE; POLY(LACTIC ACID); POLYLACTIC ACID; MELT RHEOLOGY; DEGRADATION; TRANSITION; RELEASE; BULK; PLA;

D O I：

10.1002/pat.5757

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The mechanical properties of polylactic acid (PLA), largely determined by its molecular weight and tacticity, can be modified by copolymerization and multi-armed structure, among other things. A series of liquid PEG(4)-PLA copolymers bearing various PDLLA or PLLA of increasing molecular weights was synthesized and characterized. The glass transition temperature and viscosity gradually increased with the molecular weight and the optical purity of the copolymer's PLA segment. The release profiles of two model drugs, bupivacaine HCl and bovine serum albumin were comparable, and controlled by the molecular weight and dissolution of the polymeric carrier. These findings can help in the development of new applications in biomedicine in which viscosity plays a significant role.

引用

页码：3782 / 3787

页数：6

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