Acute stress-induced change in polysialic acid levels mediated by sialidase in mouse brain

被引：21

作者：

Abe, Chikara ^{[1
]}

Yi, Yang ^{[1
]}

Hane, Masaya ^{[1
]}

Kitajima, Ken ^{[1
]}

Sato, Chihiro ^{[1
]}

机构：

[1] Nagoya Univ, Biosci & Biotechnol Ctr, Nagoya, Aichi 4648601, Japan

来源：

SCIENTIFIC REPORTS | 2019年 / 9卷 / 1期

关键词：

CELL-ADHESION MOLECULE; PSA-NCAM; STRUCTURAL PLASTICITY; TAIL SUSPENSION; MUTATED POLYSIALYLTRANSFERASE; FUNCTIONAL IMPAIRMENTS; NEURITE OUTGROWTH; PREFRONTAL CORTEX; SYNAPTIC PROTEINS; RESTRAINT STRESS;

D O I：

10.1038/s41598-019-46240-6

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Stress is an important environmental factor influencing human behaviour and causing several mental disorders. Alterations in the structure of polysialic acid (polySia/PSA) due to genetic alterations in ST8SIA2, which encodes a polySia-synthesizing enzyme, are related to certain mental disorders. However, whether stress as an environmental factor leads to changes in polySia structure is unknown. Here we studied the effects of acute stress on polySia expression and found reductions in both the quantity and quality of polySia in the olfactory bulb and prefrontal cortex, even with short-term exposure to acute stress. The use of inhibitors for sialidase, microglia and astrocytes revealed that these declines were due to a transient action of sialidase from microglia and astrocytes in the olfactory bulb and prefrontal cortex, respectively. These data suggest that sialidase dynamically regulates polySia expression in a brain region-specific manner.

引用

页数：14

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