Methodology to Obtain a Mixed Sural Nerve Recording in Mice

Objective: There is an increasing interest in using mouse models for electrodiagnostic research. Studying transgenic mice with various pathologies adds to our knowledge of the natural history of a disease. It is imperative, however, to compare disease models with the appropriate control. Design: For these animals to be used in electrodiagnostic research, reference values must be set. If reference values are not available, the validity of data are highly questionable. We propose a method of obtaining mixed nerve action potentials and collect reference values from the sural nerve of mice. Results: The results were a mean peak latency of 1.74 msecs on the right and 1.89 msecs on the left. The mean amplitude was 17.0 mu V on the left and 21.6 mu V on the right. Conclusions: In future studies, these reference values can be useful tools in analysis of murine subjects.