Involvement of heparanase in tumor metastases: A new target in cancer therapy?

被引:15
作者
Boyd, DD
Nakajima, M
机构
[1] MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA
[2] Novartis, Tsukuba, Ibaraki, Japan
关键词
D O I
10.1093/jnci/djh256
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:1194 / 1195
页数:2
相关论文
共 10 条
[1]   Heparanase gene silencing, tumor invasiveness, angiogenesis, and metastasis [J].
Edovitsky, E ;
Elkin, M ;
Zcharia, E ;
Peretz, T ;
Vlodavsky, I .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2004, 96 (16) :1219-1230
[2]   Heparanase induces endothelial cell migration via protein kinase B/Akt activation [J].
Gingis-Velitski, S ;
Zetser, A ;
Flugelman, MY ;
Vlodavsky, I ;
Ilan, N .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (22) :23536-23541
[3]   Cell surface expression and secretion of heparanase markedly promote tumor angiogenesis and metastasis [J].
Goldshmidt, O ;
Zcharia, E ;
Abramovitch, R ;
Metzger, S ;
Aingorn, H ;
Friedmann, Y ;
Schirrmacher, V ;
Mitrani, E ;
Vlodavsky, I .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (15) :10031-10036
[4]   Increased stromal expression of murine urokinase plasminogen activator in a human breast cancer xenograft model following treatment with the matrix metalloprotease inhibitor, batimastat [J].
Holst-Hansen, C ;
Low, JA ;
Stephens, RW ;
Johnson, MD ;
Carmeliet, P ;
Frandsen, TL ;
Brünner, N ;
Dickson, RB .
BREAST CANCER RESEARCH AND TREATMENT, 2001, 68 (03) :225-237
[5]  
Krüger A, 2001, CANCER RES, V61, P1272
[6]   Functional overlap between two classes of matrix-degrading proteases in wound healing [J].
Lund, LR ;
Romer, J ;
Bugge, TH ;
Nielsen, BS ;
Frandsen, TL ;
Degen, JL ;
Stephens, RW ;
Dano, K .
EMBO JOURNAL, 1999, 18 (17) :4645-4656
[7]   Cloning and expression profiling of Hpa2, a novel mammalian heparanase family member [J].
McKenzie, E ;
Tyson, K ;
Stamps, A ;
Smith, P ;
Turner, P ;
Barry, R ;
Hircock, M ;
Patel, S ;
Barry, E ;
Stubberfield, C ;
Terrett, J ;
Page, M .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 276 (03) :1170-1177
[8]   Human heparanase - Purification, characterization, cloning, and expression [J].
Toyoshima, M ;
Nakajima, M .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (34) :24153-24160
[9]  
Uno F, 2001, CANCER RES, V61, P7855
[10]   Mammalian heparanase: Gene cloning, expression and function in tumor progression and metastasis [J].
Vlodavsky, I ;
Friedmann, Y ;
Elkin, M ;
Aingorn, H ;
Atzmon, R ;
Ishai-Michaeli, R ;
Bitan, M ;
Pappo, O ;
Peretz, T ;
Michal, I ;
Spector, L ;
Pecker, I .
NATURE MEDICINE, 1999, 5 (07) :793-802