Regulation of immune responses by the airway epithelial cell landscape

被引：332

作者：

Hewitt, Richard J. ^{[1
]}

Lloyd, Clare M. ^{[1
]}

机构：

[1] Imperial Coll London, Natl Heart & Lung Inst, London, England

来源：

NATURE REVIEWS IMMUNOLOGY | 2021年 / 21卷 / 06期

基金：

英国惠康基金;

关键词：

PULMONARY NEUROENDOCRINE CELLS; BASAL-CELLS; T-CELLS; CHEMOSENSORY CELLS; NEUROMEDIN-U; CLARA CELLS; STEM-CELLS; LUNG; TISSUE; LIFE;

D O I：

10.1038/s41577-020-00477-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The community of cells lining our airways plays a collaborative role in the preservation of immune homeostasis in the lung and provides protection from the pathogens and pollutants in the air we breathe. In addition to its structural attributes that provide effective mucociliary clearance of the lower airspace, the airway epithelium is an immunologically active barrier surface that senses changes in the airway environment and interacts with resident and recruited immune cells. Single-cell RNA-sequencing is illuminating the cellular heterogeneity that exists in the airway wall and has identified novel cell populations with unique molecular signatures, trajectories of differentiation and diverse functions in health and disease. In this Review, we discuss how our view of the airway epithelial landscape has evolved with the advent of transcriptomic approaches to cellular phenotyping, with a focus on epithelial interactions with the local neuronal and immune systems.

引用

页码：347 / 362

页数：16

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