Wnt/beta-catenin pathway: modulating anticancer immune response

被引：550

作者：

Pai, Sachin Gopalkrishna ^{[1
,2
,3
]}

Carneiro, Benedito A. ^{[1
,2
]}

Mota, Jose Mauricio ^{[4
]}

Costa, Ricardo ^{[1
,2
]}

Leite, Caio Abner ^{[5
]}

Barroso-Sousa, Romualdo ^{[6
]}

Kaplan, Jason Benjamin ^{[1
,2
]}

Chae, Young Kwang ^{[1
,2
]}

Giles, Francis Joseph ^{[1
,2
]}

机构：

[1] Feinberg Sch Med, Div Hematol Oncol, Dev Therapeut Program, Chicago, IL 60611 USA

[2] Northwestern Univ, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA

[3] Univ S Alabama, Mitchell Canc Inst, Dept Interdisciplinary Clin Oncol, 1660 Springhill Ave, Mobile, AL 36688 USA

[4] Univ Sao Paulo, Inst Canc Estado Sao Paulo, Sao Paulo, Brazil

[5] AC Camargo Canc Ctr, Sao Paulo, Brazil

[6] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

来源：

JOURNAL OF HEMATOLOGY & ONCOLOGY | 2017年 / 10卷

关键词：

Wnt; beta-catenin; Immunotherapy; Cancer immune regulation; Immune exclusion; MAMMARY-TUMOR VIRUS; TRANSCRIPTION FACTOR LEF-1; BREAST-CANCER METASTASIS; RENAL-CELL CARCINOMA; BETA-CATENIN; WNT PATHWAY; STEM-CELLS; DENDRITIC CELLS; GENE-EXPRESSION; T-CELLS;

D O I：

10.1186/s13045-017-0471-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Wnt/beta-catenin signaling, a highly conserved pathway through evolution, regulates key cellular functions including proliferation, differentiation, migration, genetic stability, apoptosis, and stem cell renewal. The Wnt pathway mediates biological processes by a canonical or noncanonical pathway, depending on the involvement of beta-catenin in signal transduction. beta-catenin is a core component of the cadherin protein complex, whose stabilization is essential for the activation of Wnt/beta-catenin signaling. As multiple aberrations in this pathway occur in numerous cancers, WNT-directed therapy represents an area of significant developmental therapeutics focus. The recently described role of Wnt/beta-catenin pathway in regulating immune cell infiltration of the tumor microenvironment renewed the interest, given its potential impact on responses to immunotherapy treatments. This article summarizes the role of Wnt/beta-catenin pathway in cancer and ongoing therapeutic strategies involving this pathway.

引用

页数：12

共 103 条

[1] Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials [J].

Algra, Annemijn M. ;

Rothwell, Peter M. .

LANCET ONCOLOGY, 2012, 13 (05) :518-527

[2] Dendritic Cell-Specific Deletion of β-Catenin Results in Fewer Regulatory T-Cells without Exacerbating Autoimmune Collagen-Induced Arthritis [J].

Alves, C. Henrique ;

Ober-Blobaum, Julia L. ;

Brouwers-Haspels, Inge ;

Asmawidjaja, Patrick S. ;

Mus, Adriana M. C. ;

Razawy, Wida ;

Molendijk, Marlieke ;

Clausen, Bjorn E. ;

Lubberts, Erik .

PLOS ONE, 2015, 10 (11)

[3]

[Anonymous], J CLIN ONCOL

[4] Multilayer-omics analysis of renal cell carcinoma, including the whole exome, methylome and transcriptome [J].

Arai, Eri ;

Sakamoto, Hiromi ;

Ichikawa, Hitoshi ;

Totsuka, Hirohiko ;

Chiku, Suenori ;

Gotoh, Masahiro ;

Mori, Taisuke ;

Nakatani, Tamao ;

Ohnami, Sumiko ;

Nakagawa, Tohru ;

Fujimoto, Hiroyuki ;

Wang, Linghua ;

Aburatani, Hiroyuki ;

Yoshida, Teruhiko ;

Kanai, Yae .

INTERNATIONAL JOURNAL OF CANCER, 2014, 135 (06) :1330-1342

[5] The CREB-Binding Protein Inhibitor ICG-001 Suppresses Pancreatic Cancer Growth [J].

Arensman, Michael D. ;

Telesca, Donatello ;

Lay, Anna R. ;

Kershaw, Kathleen M. ;

Wu, Nanping ;

Donahue, Timothy R. ;

Dawson, David W. .

MOLECULAR CANCER THERAPEUTICS, 2014, 13 (10) :2303-2314

[6] Tankyrase Inhibition Blocks Wnt/β-Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal Cancer [J].

Arques, Oriol ;

Chicote, Irene ;

Puig, Isabel ;

Tenbaum, Stephan P. ;

Argiles, Guillem ;

Dienstmann, Rodrigo ;

Fernandez, Natalia ;

Caratu, Ginevra ;

Matito, Judit ;

Silberschmidt, Daniel ;

Rodon, Jordi ;

Landolfi, Stefania ;

Prat, Aleix ;

Espin, Eloy ;

Charco, Ramon ;

Nuciforo, Paolo ;

Vivancos, Ana ;

Shao, Wenlin ;

Tabernero, Josep ;

Palmer, Hector G. .

CLINICAL CANCER RESEARCH, 2016, 22 (03) :644-656

[7] Immune cell recruitment in teratomas is impaired by increased Wnt secretion [J].

Augustin, Iris ;

Dewi, Dyah L. ;

Hundshammer, Jennifer ;

Rempel, Eugen ;

Brunk, Fabian ;

Boutros, Michael .

STEM CELL RESEARCH, 2016, 17 (03) :607-615

[8] Chronic chemotherapeutic stress promotes evolution of stemness and WNT/beta-catenin signaling in colorectal cancer cells: implications for clinical use of WNT-signaling inhibitors [J].

Ayadi, Meriam ;

Bouygues, Anais ;

Ouaret, Djamila ;

Ferrand, Nathalie ;

Chouaib, Salem ;

Thiery, Jean-Paul ;

Muchardt, Christian ;

Sabbah, Michele ;

Larsen, Annette K. .

ONCOTARGET, 2015, 6 (21) :18518-18533

[9] Functional interaction of an axin homolog, conductin, with β-catenin, APC, and GSK3β [J].

Behrens, J ;

Jerchow, BA ;

Würtele, M ;

Grimm, J ;

Asbrand, C ;

Wirtz, R ;

Kühl, M ;

Wedlich, D ;

Birchmeier, W .

SCIENCE, 1998, 280 (5363) :596-599

[10] Functional interaction of beta-catenin with the transcription factor LEF-1 [J].

Behrens, J ;

vonKries, JP ;

Kuhl, M ;

Bruhn, L ;

Wedlich, D ;

Grosschedl, R ;

Birchmeier, W .

NATURE, 1996, 382 (6592) :638-642

← 1 2 3 4 5 6 7 8 9 10 →