Synthesis and antimicrobial activity of quaternary salts of the alkaloid glaucine

被引：3

作者：

Turmukhambetov, A. Zh. ^{[1
]}

Mukusheva, G. K. ^{[1
]}

Seidakhmetova, R. B. ^{[1
]}

Shults, E. E. ^{[2
]}

Shakirov, M. M. ^{[2
]}

Bagryanskaya, I. Yu. ^{[2
]}

Gatilov, Yu. V. ^{[2
]}

Adekenov, S. M. ^{[1
]}

机构：

[1] Phytochem Res & Prod Ctr, Karaganda 100009, Kazakhstan

[2] Russian Acad Sci, Vorozhtsov Inst Organ Chem, Siberian Branch, Novosibirsk 630090, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2009年 / 43卷 / 05期

关键词：

aporphine alkaloids; glaucine; ethyl iodide and methyl iodide of tetramethoxyaporphine; x-ray structure analysis; antimicrobial activity;

D O I：

10.1007/s11094-009-0283-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Quaternary salts of the alkaloid glaucine with alkyl iodides have been obtained. The crystal and molecular structure of the methyl iodide salt was studied by x-ray structure analysis. The synthesized compounds were tested for antimicrobial activity with respect to both Gram-positive (Staphylococcus aureus, Bacillus subtilis) and Gram-negative (Escherichia coli) bacteria.

引用

页码：255 / 257

页数：3

共 11 条

[1]

[Anonymous], 1998, SHELX 97 RELEASE 97

[2]

[Anonymous], 1975, Chemistry

[3] 5-HT1A-RECEPTOR ANTAGONISM - N-ALKYL DERIVATIVES OF (R)-(-)-8,11-DIMETHOXYNORAPORPHINE [J].

CANNON, JG ;

JACKSON, H ;

LONG, JP ;

LEONARD, P ;

BHATNAGAR, RK .

JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (08) :1959-1962

[4]

EGOROV NS, 2004, PRINCIPLES ANTIBIOTI

[5]

MAKSYUTINA NP, 1983, PLANT AGENTS

[6]

Navashin S.M., 1982, RATIONAL ANTIBIOTIC

[7]

RAM VJ, 1998, LIEBIGS ANN CHEM, P1085

[8]

Sadritdinov F. S., 1980, PHARM PLANT ALKALOID

[9]

SCUTORAS C, 1996, SYNTHETIC COMMUN, V26, P2251

[10] HOFMANN DEGRADATION OF BETA-HYDROXY AMMONIUM-SALTS - ALPHA-HYDROXYLAUDANOSINE AND BETA-HYDROXYLAUDANOSINE, 7-HYDROXYGLAUCINE, AND 13-HYDROXYXYLOPININE [J].

WERT, KL ;

CHACKALAMANNIL, S ;

MILLER, E ;

DALTON, DR ;

ZACHARIAS, DE ;

GLUSKER, JP .

JOURNAL OF ORGANIC CHEMISTRY, 1982, 47 (26) :5141-5150

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