Asymmetric total synthesis of naturally occurring spirocyclic tetranorsesquiterpenoid lanceolactone A

被引：19

作者：

Acharyya, Ranjan Kumar ^{[1
]}

Nanda, Samik ^{[1
]}

机构：

[1] Indian Inst Technol Kharagpur, Dept Chem, Kharagpur, W Bengal, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2018年 / 16卷 / 27期

关键词：

GAMMA-ALKYLIDENEBUTENOLIDES; CYCLIZATION; DEIODINATION; RAMARIOLIDES; BUTENOLIDES; ANHYDRIDES; ALKENES; REAGENT; ACIDS;

D O I：

10.1039/c8ob01328d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Asymmetric total synthesis of naturally occurring gamma-butenolide containing [4.4]spiro-tetrahydrofuran lanceolactone A has been reported in the present work. Bimetallic ("Pd-Cu") cascade cyclization was the crucial reaction employed for the construction of the gamma-butenolide framework of the natural product. Subsequently, iodocyclization and reductive deiodination through a transfer hydrogenation reaction were applied to access the target molecule in an efficient manner.

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收藏

页码：5027 / 5035

页数：9

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