A practical synthesis of 1,4,7,10-tetraazacyclododecane, a pivotal precursor for MRI contrast agents

被引：8

作者：

Ferrari, M

Giovenzana, GB

Palmisano, G

Sisti, M

机构：

[1] MMFFNN, Fac Sci, Dipartimento Sci Chim Fis & Matemat, I-22100 Como, Italy

[2] MMFFNN, Fac Sci, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy

[3] Fac Farm, Dipartimento Sci Med, I-28100 Novara, Italy

来源：

SYNTHETIC COMMUNICATIONS | 2000年 / 30卷 / 01期

关键词：

D O I：

10.1080/00397910008087287

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A practical preparation of the versatile macrocycle 1,4,7,10-tetraazacyclododecane (cyclen) was developed starting from cheap and easily available starting materials as ethylenediamine and glyoxal.

引用

页码：15 / 21

页数：7

共 15 条

[1]

AGRESE M, Patent No. 49691

[2]

AIME S, 1997, CHEM SOC REV, V26, P1

[3]

FUCHS B, 1979, RECL TRAV CHIM PAY B, V98, P326

[4] A new route to cyclen, cyclam and homocyclen. [J].

Hervé, G ;

Bernard, H ;

Le Bris, N ;

Yaouanc, JJ ;

Handel, H ;

Toupet, L .

TETRAHEDRON LETTERS, 1998, 39 (38) :6861-6864

[5]

MUELLER R, 1991, TETRAHEDRON, V47, P1013

[6] TRIFLAMIDES FOR PROTECTION AND CYCLIZATION OF TETRAAMINES TO TETRAAZAMACROCYCLES [J].

PANETTA, V ;

YAOUANC, JJ ;

HANDEL, H .

TETRAHEDRON LETTERS, 1992, 33 (38) :5505-5508

[7] NITROGEN ANALOGS OF CROWN ETHERS [J].

RICHMAN, JE ;

ATKINS, TJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1974, 96 (07) :2268-2270

[8]

RICHMAN JE, 1978, ORG SYNTH, V58, P86

[9]

SANDNES RW, Patent No. 28432

[10] HIGH-YIELD SYNTHESIS AND CRYSTAL-STRUCTURE OF 1,5,9,13-TETRAAZACYCLOHEXADECANE ([16]ANEN4) [J].

SMITH, WL ;

EKSTRAND, JD ;

RAYMOND, KN .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1978, 100 (11) :3539-3544

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