Genomic organization of the human bone morphogenetic protein-4 gene: Molecular basis for multiple transcripts

被引：26
|
作者：
vandenWijngaard, A [1 ]
vanKraay, M [1 ]
vanZoelen, EJJ [1 ]
Olijve, W [1 ]
Boersma, CJC [1 ]
机构：
[1] UNIV NIJMEGEN,CELL BIOL LAB,6525 ED NIJMEGEN,NETHERLANDS
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 219卷 / 03期
关键词：
D O I：
10.1006/bbrc.1996.0312
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The structure of the human bone morphogenetic protein-4 (BMP-4) gene has been characterized from a genomic cosmid clone of about 38 kb. The transcriptional unit of the human BMP-4 gene is encoded by 5 exons and spans approximately 7 kb. The exon/intron organization of the human BMP-4 gene is similar to that of the mouse gene, with notable sequence differences in the 5' non-coding exons. The human BMP-4 gene has at least two functional promoters, which are used in a cell type specific manner. This observation is of fundamental relevance for understanding the specific role of BMP-4 in skeletal development and bone remodeling. (C) 1996 Academic Press, Inc.
引用
收藏
页码：789 / 794
页数：6
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