Biosynthesis of fungal indole alkaloids

被引：176

作者：

Xu, Wei ^{[1
]}

Gavia, Diego J. ^{[2
]}

Tang, Yi ^{[1
,2
]}

机构：

[1] Univ Calif Los Angeles, Dept Chem & Biomol Engn, Los Angeles, CA 90096 USA

[2] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

来源：

NATURAL PRODUCT REPORTS | 2014年 / 31卷 / 10期

关键词：

NONRIBOSOMAL PEPTIDE SYNTHETASE; DITERPENE GENE-CLUSTER; CELL CYCLE INHIBITORS; ASPERGILLUS-FUMIGATUS; ADENYLATION DOMAINS; DIMETHYLALLYLTRYPTOPHAN SYNTHASE; DIRECTED BIOSYNTHESIS; MULTICYCLIC SCAFFOLDS; COMPLEXITY GENERATION; NATURAL-PRODUCTS;

D O I：

10.1039/c4np00073k

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review provides a summary of recent research advances in elucidating the biosynthesis of fungal indole alkaloids. The different strategies used to incorporate and derivatize the indole/indoline moieties in various families of fungal indole alkaloids will be discussed, including tryptophan-containing nonribosomal peptides, polyketide-nonribosomal peptide hybrids, and alkaloids derived from other indole building blocks. This review also includes a discussion regarding the downstream modifications that generate chemical and structural diversity among indole alkaloids.

引用

页码：1474 / 1487

页数：14

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