Decreased L-arginine-nitric oxide pathway in cultured myoblasts from spontaneously hypertensive versus normotensive Wistar-Kyoto rats

被引：17
|
作者：
Dubois, G
机构：
[1] Pharmacologie des Regulations C., CNRS URA 1482, Faculte de Médecine Necker, 75730 Paris Cedex 15, 156, rue de Vaugirard
来源：
FEBS LETTERS | 1996年 / 392卷 / 03期
关键词：
spontaneously hypertensive rat; nitric oxide synthase; smooth muscle cell;
D O I：
10.1016/0014-5793(96)00817-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The hypertrophy of the arterial media exhibited by spontaneously hypertensive rats is related to the hyperproliferation of their smooth muscle cells in culture, Using two methods to assay nitric oxide synthase activity, we showed that this abnormal proliferation results from a decreased activity of the inducible NOS II and less modulation of this enzymatic activity by these cells compared to control Wistar Kyoto cells.
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页码：242 / 244
页数：3
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