The rise of regulatory RNA

被引：1025
作者：
Morris, Kevin V. [1 ,2 ]
Mattick, John S. [1 ,3 ,4 ]
机构：
[1] Univ New S Wales, Sch Biotechnol & Biomed Sci, Sydney, NSW 2052, Australia
[2] Scripps Res Inst, La Jolla, CA 92037 USA
[3] St Vincents Hosp, Garvan Inst Med Res, Darlinghurst, NSW 2010, Australia
[4] Univ New S Wales, St Vincents Clin Sch, Sydney, NSW 2052, Australia
来源：
NATURE REVIEWS GENETICS | 2014年 / 15卷 / 06期
基金：
英国医学研究理事会; 澳大利亚研究理事会; 美国国家卫生研究院;
关键词：
LONG NONCODING RNAS; SMALL INTERFERING RNAS; GENOME-WIDE ANALYSIS; PROTEIN-CODING RNA; MESSENGER-RNA; TRANSCRIPTION INITIATION; TRANSPOSABLE ELEMENTS; ANTISENSE RNA; TINY RNAS; L1; RETROTRANSPOSITION;
D O I：
10.1038/nrg3722
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence suggests that RNA is not only functional as a messenger between DNA and protein but also involved in the regulation of genome organization and gene expression, which is increasingly elaborate in complex organisms. Regulatory RNA seems to operate at many levels; in particular, it plays an important part in the epigenetic processes that control differentiation and development. These discoveries suggest a central role for RNA in human evolution and ontogeny. Here, we review the emergence of the previously unsuspected world of regulatory RNA from a historical perspective.
引用
收藏
页码：423 / 437
页数：15
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