Chronic Inflammatory Demyelinating Polyneuropathy after Treatment with Interferon-α

被引：9

作者：

Hirotani, Makoto ^{[1
]}

Nakano, Hitoshi ^{[2
]}

Ura, Shigehisa ^{[2
]}

Yoshida, Kazuto ^{[2
]}

Niino, Masaaki ^{[1
]}

Yabe, Ichiro ^{[1
]}

Sasaki, Hidenao ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Med, Dept Neurol, Sapporo, Hokkaido, Japan

[2] Asahikawa Red Cross Hosp, Dept Neurol, Asahikawa, Hokkaido, Japan

来源：

INTERNAL MEDICINE | 2009年 / 48卷 / 05期

关键词：

chronic inflammatory demyelinating polyneuropathy; hepatitis C virus; interferon-alpha; HEPATITIS-C-VIRUS; DENDRITIC CELLS; INFECTION;

D O I：

10.2169/internalmedicine.48.1616

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Interferon-alpha (IFN-alpha), though widely used for the treatment of chronic viral hepatitis, may be associated with the occurrence of autoimmune disorders. In this case report, a patient with chronic hepatitis C virus infection had chronic inflammatory demyelinating polyneuropathy (CIDP) after the initiation of IFN-alpha therapy. The neurological symptoms of this patient continued to progress even though the treatment with IFN-alpha had been withdrawn; the symptoms improved dramatically following treatment with intravenous immunoglobulin. This case may therefore provide an important clue to understand the immune mechanism of CIDP and IFN-alpha.

引用

页码：373 / 375

页数：3

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