Carbon Nanotube Based Artificial Water Channel Protein: Membrane Perturbation and Water Transportation

被引：105

作者：

Liu, Bo ^{[1
,2
,3
]}

Li, Xiaoyi ^{[1
,2
,3
]}

Li, Baolei ^{[4
]}

Xu, Bingqian ^{[5
,6
]}

Zhao, Yuliang ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Sci, Grad Univ, Coll Chem & Chem Engn, Beijing 100049, Peoples R China

[2] Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Inst High Energy Phys, Beijing 100049, Peoples R China

[3] Natl Ctr Nanosci & Technol China, Beijing 100049, Peoples R China

[4] Duke Univ, Dept Phys, Durham, NC 27708 USA

[5] Univ Georgia, Fac Engn & Nanoscale Sci, Athens, GA 30602 USA

[6] Univ Georgia, Ctr Engn, Athens, GA 30602 USA

来源：

NANO LETTERS | 2009年 / 9卷 / 04期

关键词：

MOLECULAR-DYNAMICS SIMULATIONS; PROTON EXCLUSION; LIPID-BILAYER; PERMEATION; CONDUCTION; DIFFUSION; AQUAPORIN-1; MECHANISM; FAMILY; DRIVEN;

D O I：

10.1021/nl8030339

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We functionalized double-walled carbon nanotubes (DWCNTs) as artificial water channel proteins. For the first time, molecular dynamics simulations show that the bilayer structure of DWCNTs is advantageous for carbon nanotube based transmembrane channels. The shielding of the amphiphilic outer layer could guarantee biocompatibility of the synthetic channel and protect the inner tube (functional part) from disturbance of the membrane environment. This novel design could promote more sophisticated nanobiodevices which could function in a bioenvironment with high biocompatibility.

引用

页码：1386 / 1394

页数：9

共 65 条

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