Synthesis of N-Boc-(R)-α-phenyl-γ-aminobutyric acid using an in situ diastereoselective protonation strategy

被引：7
作者：
Calmés, M
Escale, F
Martinez, J
机构：
[1] Univ Montpellier I, CNRS, UMR 5810, Lab Aminoacides Peptides & Prot, F-34095 Montpellier 5, France
[2] Univ Montpellier 2, CNRS, UMR 5810, Lab Aminoacides Peptides & Prot, F-34095 Montpellier 5, France
来源：
TETRAHEDRON-ASYMMETRY | 2002年 / 13卷 / 03期
关键词：
D O I：
10.1016/S0957-4166(02)00075-7
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The synthesis of (+/-)-N-phthalyl alpha-phenyl-gamma-aminobutyric acid and its asymmetric transformation via ketene formation have been investigated, allowing, after hydrolysis and amine protection, the preparation of the enantiomerically pure N-Boc-(R)-alpha-phenyl-gamma-aminobutyric acid. (C) 2002 Published by Elsevier Science Ltd.
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收藏
页码：293 / 296
页数：4
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