The Evolutionary Pathway of X Chromosome Inactivation in Mammals

被引:15
作者
Shevchenko, A. I. [1 ,2 ,3 ]
Zakharova, I. S. [1 ,2 ,3 ]
Zakian, S. M. [1 ,2 ,3 ]
机构
[1] Russian Acad Sci, Siberian Branch, Inst Cytol & Genet, Novosibirsk 630090, Russia
[2] State Res Inst Circulat Pathol, Novosibirsk 630055, Russia
[3] Russian Acad Sci, Siberian Branch, Inst Chem Biol & Fundamental Med, Novosibirsk 630090, Russia
基金
俄罗斯基础研究基金会;
关键词
mammals; X chromosome inactivation; Xist; DOSAGE COMPENSATION; XIST RNA; SEX-CHROMOSOMES; FACULTATIVE HETEROCHROMATIN; NONCODING RNA; SAF-A; GENE; MOUSE; PLATYPUS; DNA;
D O I
10.32607/20758251-2013-5-2-40-53
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
X chromosome inactivation is a complex process that occurs in marsupial and eutherian mammals. The process is thought to have arisen during the differentiation of mammalian sex chromosomes to achieve an equal dosage of X chromosome genes in males and females. The differences in the X chromosome inactivation processes in marsupial and eutherian mammals are considered, and the hypotheses on its origin and evolution are discussed in this review.
引用
收藏
页码:40 / 53
页数:14
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