Reactions of β-aminopropionic acid N′-acylhydrazides with carbonyl compounds

被引：2

作者：

Smirnov, GA ^{[1
]}

Sizova, EP ^{[1
]}

Luk'yanov, OA ^{[1
]}

机构：

[1] Russian Acad Sci, ND Zelinskii Organ Chem Inst, Moscow 119991, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2004年 / 53卷 / 03期

关键词：

3-acylaminotetrahydropyrimidin-4-ones; beta-aminopropionic acid N '-benzoylhydrazide; beta-aminopropionic acid N '-acetylhydrazide; ketones; aldehydes; N-acylation; N-tosylation; Schiff's bases; tautomeric equilibrium;

D O I：

10.1023/B:RUCB.0000035649.77800.28

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reactions of beta-aminopropionic acid N'-acylhydrazides with aromatic and heterocyclic aldehydes and acetone afford compounds that exist in solutions predominantly as mixtures of 2-substituted 3-acylaminotetrahydropyrimidin-4-ones (ATHP) and tautomeric Schiff's bases. These compounds in the crystalline state probably have structures of ATHP. The ratio of tautomers depends on the type of substituent in the aromatic ring and solvent. The reactions of 2-aryl-3-benzamidotetrahydropyrimidin-4-ones with carboxylic or sulfonic acid chlorides afford derivatives of 1-acyl- and 1-tosyl-3-benzamidotetrahydropyrimidin-4-ones.

引用

页码：635 / 640

页数：6