Endothelial progenitor cells and their potential clinical implication in cardiovascular disorders

被引：24
|
作者：
Zeoli, A. [1 ]
Dentelli, P. [1 ]
Brizzi, M. F. [1 ]
机构：
[1] Univ Turin, Dept Internal Med, I-10126 Turin, Italy
来源：
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | 2009年 / 32卷 / 04期
关键词：
Cardiovascular diseases; diabetes; endothelial progenitor cells (EPC); re-endothelialization; transplantation; ACUTE MYOCARDIAL-INFARCTION; BONE-MARROW-CELLS; COLONY-STIMULATING FACTOR; CORONARY-ARTERY-DISEASE; NITRIC-OXIDE SYNTHASE; RANDOMIZED CONTROLLED-TRIAL; SPONTANEOUSLY HYPERTENSIVE-RATS; CYTOKINE-INDUCED MOBILIZATION; LEFT-VENTRICULAR FUNCTION; HEMATOPOIETIC STEM-CELLS;
D O I：
10.1007/BF03345729
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Risk factors associated with cardiovascular diseases reduce the availability of endothelial progenitor cells (EPC) by affecting their mobilization and integration into injured vascular sites. The existence of a bone marrow reservoir of EPC has attracted interest, especially as target for therapeutic intervention in different pathological settings. Among the cardiovascular risk factors, hypertension has been shown to be a strongest predictor of EPC migratory impairment. However, at present, data concerning EPC biology are still limited. In this article we provide an overview of data relevant to their potential clinical implications in cardiovascular disorders. In addition, the recent advances in understanding the role of EPC in the pathophysiology of hypertension are discussed. (J. Endocrinol. Invest. 32: 370-382, 2009) (C)2009, Editrice Kurtis
引用
收藏
页码：370 / 382
页数：13
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