Claudin 1 Promotes Migration and Increases Sensitivity to Tamoxifen and Anticancer Drugs in Luminal-like Human Breast Cancer Cells MCF7

被引：20
|
作者：
Zhou, Bowen [1 ]
Blanchard, Anne [1 ,2 ]
Wang, Nan [2 ]
Ma, Xiuli [1 ]
Han, Jihyun [1 ]
Schroedter, Ingo [1 ]
Leygue, Etienne [3 ]
Myal, Yvonne [1 ,2 ]
机构：
[1] Univ Manitoba, Dept Pathol, Fac Hlth Sci, Coll Med, Winnipeg, MB R3T 2N2, Canada
[2] Univ Manitoba, Fac Hlth Sci, Dept Physiol & Pathophysiol, Coll Med, Winnipeg, MB, Canada
[3] Univ Manitoba, Fac Hlth Sci, Dept Biochem & Human Genet, Coll Med, Winnipeg, MB, Canada
来源：
CANCER INVESTIGATION | 2015年 / 33卷 / 09期
关键词：
Claudin; 1; Breast cancer; Tamoxifen; Migration; MCF7; Estrogen; TGF beta; GROWTH-FACTOR-BETA; EPITHELIAL-MESENCHYMAL TRANSITION; CARCINOMA-CELLS; TIGHT JUNCTIONS; TUMOR INVASION; L EXPRESSION; APOPTOSIS; CISPLATIN; ACTIVATION; ETOPOSIDE;
D O I：
10.3109/07357907.2015.1060996
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Downregulation of claudin 1, a critical tight junction protein, has been correlated with increased invasiveness in breast cancer. However, recent studies suggest that claudin 1 contributes to the progression of some molecular subtypes of breast cancer. In this study, claudin 1 promotes migration in luminal-like MCF7 human breast cancer cells and increases their sensitivity to tamoxifen, etoposide, and cisplatin. We also observed an inverse relationship between upregulation of claudin 1 and TGF beta. Collectively, our results suggest that claudin 1 has the potential to be used as a predictive marker for treatment efficacy for specific breast cancer patient subgroups.
引用
收藏
页码：429 / 439
页数：11
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