Body mass index and outcome in patients with coronary, cerebrovascular, or peripheral artery disease: findings from the FRENA registry

被引:41
|
作者
Barba, Raquel [2 ]
Bisbe, Josep [3 ]
Alcala Pedrajas, Jose Nicolas [4 ]
Toril, Jesus [5 ]
Monte, Rafael [6 ]
Sanchez Munoz-Torrero, Juan Francisco [7 ]
Monreal, Manuel [1 ]
机构
[1] Hosp Badalona Germans Trias & Pujol, Med Interna Serv, Dept Internal Med, Badalona 08916, Spain
[2] Hosp Infanta Cristina, Dept Internal Med, Madrid, Spain
[3] Hosp St Jaume, Dept Internal Med, Olot, Girona, Spain
[4] Hosp Valle de los Pedroches, Dept Internal Med, Cordoba, Spain
[5] Ctr Med & Rehabil, Dept Internal Med, Castelldefels, Spain
[6] Hosp Xeral Lugo, Dept Internal Med, Lugo, Spain
[7] Hosp San Pedro de Alcantara, Dept Internal Med, Caceres, Spain
来源
EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION | 2009年 / 16卷 / 04期
关键词
artery disease; body mass index; cardiovascular death; outcome; MYOCARDIAL-INFARCTION; CARDIOVASCULAR-DISEASE; WAIST CIRCUMFERENCE; PROSPECTIVE COHORT; ABDOMINAL OBESITY; HEART-DISEASE; WEIGHT-LOSS; MORTALITY; IMPACT; ASSOCIATION;
D O I
10.1097/HJR.0b013e32832b1818
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background The relationship between body mass index (BMI) and mortality in patients with established arterial disease remains controversial. Methods FRENA is an ongoing, observational registry of consecutive outpatients with coronary artery disease (CAD), cerebrovascular disease, or peripheral artery disease (PAD). We examined the prognostic importance of accepted BMI categories on outcome among patients in the FRENA registry. Results In April 2008, 2274 patients (mean age, 66 years) had been enrolled, of whom 14 (0.6%) were underweight; 533 (23%) normal; 1051 (46%) overweight; and 676 (30%) were obese. Over a mean follow-up of 14 months, the incidence of major cardiovascular events (myocardial infarction, ischemic stroke, or critical limb ischemia) per 100 patient-years was: 71 [95% confidence interval (CI): 0.4-35]; 11 (95% CI: 8.4-14); 6.9 (95% CI: 5.6-8.5); and 8.5 (95% CI: 6.6-11), respectively. Their cardiovascular mortality was: 7.1 (95% CI: 0.4-35); 4.1 (95% CI: 5.9-11); 1.3 (95% CI: 0.9-2.3); and 1.5 (95% CI: 1.43.5), respectively. On multivariate analysis, the hazard ratio for cardiovascular mortality was: 2.2 (95% CI: 0.3-17); 1.0 (reference); 0.37 (95% CI: 0.20-0.69); and 0.37 (95% CI: 0.18-0.73), respectively. Survival benefit was only found in patients with CAD or PAD. Weight loss had little influence on outcome. Conclusion Patients with CAD or PAD (not those with cerebrovascular disease) have an inverse correlation between BMI and cardiovascular mortality, even after adjusting for confounding variables. Eur J Cardiovasc Prev Rehabil 16:457-463 (C) 2009 The European Society of Cardiology
引用
收藏
页码:457 / 463
页数:7
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