Cetyltrimethylammonium bromide-nanocrystalline cellulose (CTAB-NCC) based microemulsions for enhancement of topical delivery of curcumin

被引：48

作者：

Zainuddin, Norhidayu ^{[1
]}

Ahmad, Ishak ^{[1
,2
]}

Zulfakar, Mohd Hanif ^{[3
]}

Kargarzadeh, Hanieh ^{[4
]}

Ramli, Suria ^{[1
,2
]}

机构：

[1] Univ Kebangsaan Malaysia, Fac Sci & Technol, Dept Chem Sci, Bangi 43600, Selangor, Malaysia

[2] Univ Kebangsaan Malaysia, Fac Sci & Technol, Polymer Res Ctr, Bangi 43600, Selangor, Malaysia

[3] Univ Kebangsaan Malaysia, Fac Pharm, Ctr Drug Delivery Technol, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia

[4] Polish Acad Sci, Ctr Mol & Macromol Studies, Sienkiewicza 112, PL-90363 Lodz, Poland

来源：

CARBOHYDRATE POLYMERS | 2021年 / 254卷

关键词：

Nanotechnology; Topical drug carrier; Bioavailability; Skin retention; Higuchi release; DRUG-DELIVERY; NANOPARTICLES; SKIN; FORMULATION; BIOAVAILABILITY; PERMEATION; BINDING; SYSTEM; PHASE;

D O I：

10.1016/j.carbpol.2020.117401

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Low bioavailability and poor water solubility have limited the utilization of curcumin in conventional dosing methods. As an alternative, microemulsions as drug carrier can improve curcumin delivery. A cetyltrimethylammonium bromide-nanocrystalline cellulose (CTAB-NCC)-based micmemulsion was developed and its potential use as a topical delivery method for curcumin was investigated. The effect of microemulsion's particle size and its microstructure as well as the presence of the CTAB-NCC nanoparticle on the topical delivery of curcumin was studied. In vitro permeation studies showed higher penetration rate of curcumin from the oil-in-water type-micmemulsions. The skin permeation profile of curcumin followed Higuchi release kinetics. Furthermore, use of the (CTAB-NCC)-based microemulsion enhanced curcumin accumulation in the skin and these system showed non cytotoxicity effect on L929 cell line. These results showed the potential of (CTAB-NCC)-based microemulsions as controlled-release topical systems for the delivery of curcumin and potentially other lipophilic drugs.

引用

页数：9