Total synthesis of (S)-equol

被引：52

作者：

Heemstra, Jennifer M.

Kerrigan, Sean A.

Doerge, Daniel R.

Helferich, William G.

Boulanger, William A.

机构：

[1] Obiter Res LLC, Urbana, IL 61802 USA

[2] US FDA, Natl Ctr Toxicol Res, Div Biochem Toxicol, Jefferson, AR 72079 USA

[3] Univ Illinois, Dept Food Sci & Human Nutr, Urbana, IL 61801 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 24期

关键词：

D O I：

10.1021/ol0620444

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first enantioselective total synthesis of (S)-equol is reported. The described route relies on an Evans alkylation to form the stereocenter and an intramolecular Buchwald etherification to generate the chroman ring. Key features of this method include its brevity, its scalability, and the low cost of starting materials.

引用

页码：5441 / 5443

页数：3

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