SnapShot: Interferon Signaling

被引：58

作者：

Chow, Kwan T. ^{[1
]}

Gale, Michael, Jr. ^{[1
]}

机构：

[1] Univ Washington, Sch Med, Ctr Innate Immun & Immune Dis, Dept Immunol, Seattle, WA 98109 USA

来源：

CELL | 2015年 / 163卷 / 07期

关键词：

RECEPTOR; STATS;

D O I：

10.1016/j.cell.2015.12.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interferons (IFNs) are crucial cytokines of antimicrobial, antitumor, and immunomodulatory activity. The three types of IFN (I, II, and III) are classified by their receptor specificity and sequence homology. IFNs are produced and secreted by cells in response to specific stimuli. Here, we review the subsequent IFN signaling events occurring through unique receptors leading to regulation of gene expression for modulation of innate and adaptive immunity. To view this SnapShot, open or download the PDF.

引用

页数：2

共 10 条

[1] Structural basis of a unique interferon-β signaling axis mediated via the receptor IFNAR1 [J].

de Weerd, Nicole A. ;

Vivian, Julian P. ;

Nguyen, Thao K. ;

Mangan, Niamh E. ;

Gould, Jodee A. ;

Braniff, Susie-Jane ;

Zaker-Tabrizi, Leyla ;

Fung, Ka Yee ;

Forster, Samuel C. ;

Beddoe, Travis ;

Reid, Hugh H. ;

Rossjohn, Jamie ;

Hertzog, Paul J. .

NATURE IMMUNOLOGY, 2013, 14 (09) :901-+

[2] Serine phosphorylation of STATs [J].

Decker, T ;

Kovarik, P .

ONCOGENE, 2000, 19 (21) :2628-2637

[3] Regulation of type I interferon responses [J].

Ivashkiv, Lionel B. ;

Donlin, Laura T. .

NATURE REVIEWS IMMUNOLOGY, 2014, 14 (01) :36-49

[4] Type I IFNs Downregulate Myeloid Cell IFN-γ Receptor by Inducing Recruitment of an Early Growth Response 3/NGFI-A Binding Protein 1 Complex That Silences ifngr1 Transcription [J].

Kearney, Staci J. ;

Delgado, Christine ;

Eshleman, Emily M. ;

Hill, Krista K. ;

O'Connor, Brian P. ;

Lenz, Laurel L. .

JOURNAL OF IMMUNOLOGY, 2013, 191 (06) :3384-3392

[5] STATus Report on Tetramers [J].

Levy, David E. ;

Marie, Isabelle J. .

IMMUNITY, 2012, 36 (04) :553-555

[6] IL-29 and IFNα differ in their ability to modulate IL-12 production by TLR-activated human macrophages and exhibit differential regulation of the IFNγ receptor expression [J].

Liu, Bi-Sheng ;

Janssen, Harry L. A. ;

Boonstra, Andre .

BLOOD, 2011, 117 (08) :2385-2395

[7]

ODENDALL C, 2008, PLOS PATHOG, V4

[8] The unique regulation and functions of type III interferons in antiviral immunity [J].

Odendall, Charlotte ;

Kagan, Jonathan C. .

CURRENT OPINION IN VIROLOGY, 2015, 12 :47-52

[9] Mechanisms of type-I- and type-II-interferon-mediated signalling [J].

Platanias, LC .

NATURE REVIEWS IMMUNOLOGY, 2005, 5 (05) :375-386

[10] Roles of unphosphorylated STATs in signaling [J].

Yang, Jinbo ;

Stark, George R. .

CELL RESEARCH, 2008, 18 (04) :443-451

← 1 →