ZnO Nanostructures for Drug Delivery and Theranostic Applications

被引:170
作者
Martinez-Carmona, Marina [1 ,2 ]
Gun'ko, Yurii [1 ,2 ]
Vallet-Regi, Maria [3 ,4 ]
机构
[1] Univ Dublin, Trinity Coll, Sch Chem, Dublin 2, Ireland
[2] Univ Dublin, Trinity Coll, CRANN, Dublin 2, Ireland
[3] Univ Complutense Madrid, Inst Invest Sanitaria Hosp 12 Octubre I 12, Sch Pharm, Dept Chem Pharmaceut Sci, Madrid 28040, Spain
[4] CIBER BBN, Ave Monforte Lemos 3-5, Madrid 28029, Spain
基金
欧洲研究理事会;
关键词
ZnO nanoparticles; Quantum dots; theranostic; drug delivery; anti-tumour; diabetes treatment; anti-inflammation; antibacterial; antifungal; wound healing; ZINC-OXIDE NANOPARTICLES; MESOPOROUS SILICA NANOPARTICLES; QUANTUM DOTS; ANTIMICROBIAL ACTIVITY; IN-VIVO; VISIBLE PHOTOLUMINESCENCE; ANTIBACTERIAL ACTIVITY; ANTIDIABETIC ACTIVITY; SURFACE MODIFICATION; BIOLOGICAL SYNTHESIS;
D O I
10.3390/nano8040268
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
In the last two decades, zinc oxide (ZnO) semiconductor Quantum dots (QDs) have been shown to have fantastic luminescent properties, which together with their low-cost, low-toxicity and biocompatibility have turned these nanomaterials into one of the main candidates for bio-imaging. The discovery of other desirable traits such as their ability to produce destructive reactive oxygen species (ROS), high catalytic efficiency, strong adsorption capability and high isoelectric point, also make them promising nanomaterials for therapeutic and diagnostic functions. Herein, we review the recent progress on the use of ZnO based nanoplatforms in drug delivery and theranostic in several diseases such as bacterial infection and cancer.
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页数:27
相关论文
共 128 条
[1]   Crystalline insulin [J].
Abel, JJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1926, 12 :132-136
[2]  
AGREN MS, 1990, ACTA DERM-VENEREOL, P1
[3]   New Insights into Antibiofilm Effect of a Nanosized ZnO Coating against the Pathogenic Methicillin Resistant Staphylococcus aureus [J].
Alves, Marta M. ;
Bouchami, Ons ;
Tavares, Ana ;
Cordoba, Laura ;
Santos, Catarina F. ;
Miragaia, Maria ;
Montemor, Maria de Fatima .
ACS APPLIED MATERIALS & INTERFACES, 2017, 9 (34) :28157-28167
[4]  
[Anonymous], REACTIVE OXYGEN SPEC
[5]   Inactivation of bacterial biofilms using visible-light-activated unmodified ZnO nanorods [J].
Aponiene, Kristina ;
Serevicius, Tomas ;
Luksiene, Zivile ;
Jursenas, Saulius .
NANOTECHNOLOGY, 2017, 28 (36)
[6]   Enhanced Antibacterial Activity of Nanocrystalline ZnO Due to Increased ROS-Mediated Cell Injury [J].
Applerot, Guy ;
Lipovsky, Anat ;
Dror, Rachel ;
Perkas, Nina ;
Nitzan, Yeshayahu ;
Lubart, Rachel ;
Gedanken, Aharon .
ADVANCED FUNCTIONAL MATERIALS, 2009, 19 (06) :842-852
[7]   ZnO nanoparticles (ZnO-NPs) and their antifungal activity against coffee fungus Erythricium salmonicolor [J].
Arciniegas-Grijalba, P. A. ;
Patino-Portela, M. C. ;
Mosquera-Sanchez, L. P. ;
Guerrero-Vargas, J. A. ;
Rodriguez-Paez, J. E. .
APPLIED NANOSCIENCE, 2017, 7 (05) :225-241
[8]   Enhanced visible photoluminescence in ZnO quantum dots by promotion of oxygen vacancy formation [J].
Asok, Adersh ;
Gandhi, Mayuri N. ;
Kulkarni, A. R. .
NANOSCALE, 2012, 4 (16) :4943-4946
[9]   Advances in mesoporous silica nanoparticles for targeted stimuli-responsive drug delivery [J].
Baeza, Alejandro ;
Colilla, Montserrat ;
Vallet-Regi, Maria .
EXPERT OPINION ON DRUG DELIVERY, 2015, 12 (02) :319-337
[10]   Nanoparticles and targeted drug delivery in cancer therapy [J].
Bahrami, Behdokht ;
Hojjat-Farsangi, Mohammad ;
Mohammadi, Hamed ;
Anvari, Enayat ;
Ghalamfarsa, Ghasem ;
Yousefi, Mehdi ;
Jadidi-Niaragh, Farhad .
IMMUNOLOGY LETTERS, 2017, 190 :64-83