Crystal engineering of the composition of pharmaceutical phases.: Do pharmaceutical co-crystals represent a new path to improved medicines?

被引：950
作者：
Almarsson, Ö
Zaworotko, MJ
机构：
[1] TransForm Pharmaceut Inc, Lexington, MA 02421 USA
[2] Univ S Florida, Dept Chem, Tampa, FL 33620 USA
来源：
CHEMICAL COMMUNICATIONS | 2004年 / 17期
关键词：
D O I：
10.1039/b402150a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The evolution of crystal engineering into a form of supramolecular synthesis is discussed in the context of problems and opportunities in the pharmaceutical industry. Specifically, it has become clear that a wide array of multiple component pharmaceutical phases, so called pharmaceutical co-crystals, can be rationally designed using crystal engineering, and the strategy affords new intellectual property and enhanced properties for pharmaceutical substances.
引用
收藏
页码：1889 / 1896
页数：8
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