Multilamellar structures of DNA complexes with cationic liposomes

被引：58

作者：

Dan, NL

机构：

[1] Department of Chemical Engineering, University of Delaware, Newark

来源：

BIOPHYSICAL JOURNAL | 1997年 / 73卷 / 04期

关键词：

D O I：

10.1016/S0006-3495(97)78214-6

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Studies of DNA complexes with cationic liposomes are prompted by the search for nonviral DNA carriers for gene therapy. Recent experiments have identified a stable multilamellar phase in which ordered smectic layers of DNA alternate with cationic bilayers. In this paper we identify the forces governing DNA adsorption on cationic lamellae, including a membrane-induced attraction between the adsorbed DNA. Calculating the DNA interhelical spacing as a function of system composition, the model successfully explains recent surprising observations.

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收藏

页码：1842 / 1846

页数：5

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