Multilamellar structures of DNA complexes with cationic liposomes

被引：58
作者：
Dan, NL
机构：
[1] Department of Chemical Engineering, University of Delaware, Newark
来源：
BIOPHYSICAL JOURNAL | 1997年 / 73卷 / 04期
关键词：
D O I：
10.1016/S0006-3495(97)78214-6
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Studies of DNA complexes with cationic liposomes are prompted by the search for nonviral DNA carriers for gene therapy. Recent experiments have identified a stable multilamellar phase in which ordered smectic layers of DNA alternate with cationic bilayers. In this paper we identify the forces governing DNA adsorption on cationic lamellae, including a membrane-induced attraction between the adsorbed DNA. Calculating the DNA interhelical spacing as a function of system composition, the model successfully explains recent surprising observations.
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页码：1842 / 1846
页数：5
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