Palladium-catalyzed cross-coupling reactions of diazine N-oxides with aryl chlorides, bromides, and iodides

被引：244

作者：

Leclerc, Jean-Philippe ^{[1
]}

Fagnou, Keith ^{[1
]}

机构：

[1] Univ Ottawa, Dept Chem, Ctr Catalysis Res & Innovat, Ottawa, ON K1N 6N5, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 46期

关键词：

arylation; biaryls; nitrogen heterocycles; N-oxides; palladium;

D O I：

10.1002/anie.200602773

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New aspects of N-oxides: Pyrazine, pyridazine, and pyrimidine N-oxides are regioselectively arylated with aryl iodides, bromides, and chlorides in the presence of a palladium catalyst (see scheme). The resulting products can be deoxygenated in high yield or further functionalized by making use of the N-oxide functionality. FG = functional group. (Chemical Equation Presented). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：7781 / 7786

页数：6

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