Acrolein toxicity involves oxidative stress caused by glutathione depletion in the yeast Saccharomyces cerevisiae

被引：28
|
作者：
Kwolek-Mirek, M. [1 ]
Bednarska, S. [1 ]
Bartosz, G. [1 ,2 ]
Bilinski, T. [1 ]
机构：
[1] Univ Rzeszow, Dept Biochem & Cell Biol, PL-35959 Rzeszow, Poland
[2] Univ Lodz, Dept Mol Biophys, PL-90237 Lodz, Poland
来源：
CELL BIOLOGY AND TOXICOLOGY | 2009年 / 25卷 / 04期
关键词：
Yeast; Saccharomyces cerevisiae; Acrolein; Allyl alcohol; Oxidative stress; Glutathione; ALCOHOL-DEHYDROGENASE; NUCLEAR-LOCALIZATION; TRANSCRIPTION FACTOR; LIPID-PEROXIDATION; CONJUGATE; ALDEHYDES; YAP1; DEFICIENCY; ACTIVATION; MUTANTS;
D O I：
10.1007/s10565-008-9090-x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Exposure of yeast cells to allyl alcohol results in intracellular production of acrolein. The toxicity of so formed acrolein involves oxidative stress, as (1) strains deficient in antioxidant defense are hypersensitive to allyl alcohol, (2) exposure to allyl alcohol increases the level of thiobarbituric-acid-reactive substances and decreases glutathione level in the cells, (3) hypoxic and anoxic atmosphere and antioxidants protect against allyl alcohol toxicity, and (4) allyl alcohol causes activation of Yap1p. No increased formation of reactive oxygen species was detected in cells exposed to allyl alcohol, so oxidative stress is due to depletion of cellular thiols and thus alteration in the redox state of yeast cells.
引用
收藏
页码：363 / 378
页数：16
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