SIRSi compartmental model for COVID-19 pandemic with immunity loss

The coronavirus disease 2019 (Covid-19) outbreak led the world to an unprecedented health and economic crisis. In an attempt to respond to this emergency, researchers worldwide are intensively studying the dynamics of the Covid-19 pandemic. In this study, a Susceptible - Infected - Removed - Sick (SIRSi) compartmental model is proposed, which is a modification of the classical Susceptible - Infected - Removed (SIR) model. The proposed model considers the possibility of unreported or asymptomatic cases, and differences in the immunity within a population, i.e., the possibility that the acquired immunity may be temporary, which occurs when adopting one of the parameters (gamma) other than zero. Local asymptotic stability and endemic equilibrium conditions are proved for the proposed model. The model is adjusted to the data from three major cities of the state of Sao Paulo in Brazil, namely, Sao Paulo, Santos, and Campinas, providing estimations of duration and peaks related to the disease propagation. This study reveals that temporary immunity favors a second wave of infection and it depends on the time interval for a recovered person to be susceptible again. It also indicates the possibility that a greater number of patients would get infected with decreased time for reinfection. (C) 2020 Elsevier Ltd. All rights reserved.