Management of severe chronic pain with methadone in pediatric patients with sickle cell disease

被引：5

作者：

LeBlanc, Zachary ^{[1
]}

Vance, Chris ^{[2
]}

Payne, Jason ^{[3
,4
]}

Zhang, Jie ^{[4
]}

Hilliard, Lee ^{[3
]}

Lebensburger, Jeffrey D. ^{[1
,2
,3
,4
]}

Howard, Thomas H. ^{[3
]}

机构：

[1] Emory Univ, Aflac Canc & Blood Disorders Ctr, 2015 Uppergate Dr, Atlanta, GA 30322 USA

[2] Auburn Univ, Auburn, AL 36849 USA

[3] Univ Alabama Birmingham, Div Pediat Hematol Oncol, Birmingham, AL USA

[4] Univ Alabama Birmingham, Dept Epidemiol, Birmingham, AL USA

来源：

PEDIATRIC BLOOD & CANCER | 2018年 / 65卷 / 08期

关键词：

chronic pain; methadone; sickle cell disease; CHILDREN; ADULTS; RISK;

D O I：

10.1002/pbc.27084

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Vasocclusive pain crises are common among pediatric patients with sickle cell disease (SCD). Some patients with repeated pain crises develop chronic pain. We performed a retrospective cohort study of pediatric patients with SCD with chronic pain treated with methadone. We identified a significant reduction in pain hospitalizations following methadone treatment (0.35 +/- 0.19 vs. 0.19 +/- 0.17 hospitalizations/month, P=0.016). In addition, we did not observe overt organ toxicity nor symptoms of opioid withdrawal during methadone wean. We suggest that methadone is safe and has some clinical benefit, which should be proven in prospective randomized trials for pediatric patients with SCD and chronic pain.

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页数：3

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