Synthesis of 7-chloro-5-trifluoromethyl/7-fluoro/7-trifluoromethyl-4H-1,4-benzothiazines as antimicrobial agents

被引：84

作者：

Rathore, Bhawani Singh ^{[1
]}

Kumar, M. ^{[1
]}

机构：

[1] Univ Rajasthan, Dept Chem, Jaipur 302004, Rajasthan, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 16期

关键词：

4H-1,4-benzothiazines; beta-diketone/beta-ketoesters; 2-aminobenzenethiols;

D O I：

10.1016/j.bmc.2006.04.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

7-Chloro-5-trifluoromethy1/7-fluoro/7-trifluoromethyl-4H-1,4-benzothiazines have been synthesized by 2-amino-5-fluoro/5-trifluoromethyl/5-chloro-3-trifluoromethyl benzenethiols condensed with beta-diketone/beta-ketoesters in the presence of DMSO involving oxidative cyclization. Pharmacological activities have also been included. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：5678 / 5682

页数：5

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