Graft versus Host Disease: From Basic Pathogenic Principles to DNA Damage Response and Cellular Senescence

被引：28
作者：
Kuba, Adam [1 ,2 ]
Raida, Ludek [1 ,2 ]
机构：
[1] Palacky Univ, Dept Hematooncol, Univ Hosp, Olomouc, Czech Republic
[2] Palacky Univ, Fac Med & Dent, Olomouc, Czech Republic
来源：
MEDIATORS OF INFLAMMATION | 2018年 / 2018卷
关键词：
MINOR HISTOCOMPATIBILITY ANTIGENS; CONSENSUS DEVELOPMENT PROJECT; TRANSPLANT-RELATED MORTALITY; CD8(+) T-CELLS; B-CELLS; GENE POLYMORPHISMS; INTESTINAL MICROBIOTA; SECRETORY PHENOTYPE; ENDOTHELIAL-CELLS; CLINICAL-TRIALS;
D O I：
10.1155/2018/9451950
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Graft versus host disease (GVHD), a severe immunogenic complication of allogeneic hematopoietic stem cell transplantation (HSCT), represents the most frequent cause of transplant-related mortality (TRM). Despite a huge progress in HSCT techniques and posttransplant care, GVHD remains a significant obstacle in successful HSCT outcome. This review presents a complex summary of GVHD pathogenesis with focus on references considering basic biological processes such as DNA damage response and cellular senescence.
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页数：13
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