Magnetic resonance-guided interstitial therapy for vaginal recurrence of endometrial cancer

被引:68
作者
Viswanathan, Akila N.
Cormack, Robert
Holloway, Caroline L.
Tanaka, Cynthia
O'Farrell, Desmond
Devlin, Phillip M.
Tempany, Clare
机构
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Radiat Oncol, Boston, MA 02115 USA
[2] Harvard Univ, Brigham & Womens Hosp, Sch Med, Dept Radiol, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA
来源
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2006年 / 66卷 / 01期
关键词
recurrent endometrial cancer; interstitial brachytherapy; magnetic resonance;
D O I
10.1016/j.ijrobp.2006.04.037
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: To evaluate the feasibility and to describe the acute toxicity of a real-time intraoperative magnetic resonance (MR)-image guided interstitial approach to treating vaginal recurrence of endometrial cancer. Methods and Materials: From February 2004 to April 2005, 10 patients with recurrent endometrial cancer underwent MR-guided interstitial brachytherapy. Parameters evaluated included needle placement, dose-volume histograms (DVH), and complications. Results: Magnetic resonance-image guidance resulted in accurate needle placement. Tumor DVH values included median volume, 47 cc; V100, 89%; V150,61%; V200,38%; D90,71 Gy; and D100, 60 Gy. DVH of organs at risk resulted in a median D2cc of external beam and brachytherapy dose (% of brachytherapy prescription): bladder, 75Gy(3) (88%); rectum, 70Gy(3) (87%); and sigmoid, 56Gy(3) (41%). All patients experienced either a Grade 1 or 2 acute toxicity related to the radiation; only 1 patient had Grade 3 toxicity. No toxicities were attributable to the use of MR guidance. Conclusions: Real-time MR guidance during the insertion of interstitial needles reduces the likelihood of an inadvertent insertion of the needles into the bladder and the rectum. Three-dimensional dosimetry allows estimation of the dose to organs at risk. Toxicities are limited. (c) 2006 Elsevier Inc.
引用
收藏
页码:91 / 99
页数:9
相关论文
共 62 条
[1]  
BADIB AO, 1969, RADIOLOGY, V105, P596
[2]   TABLES OF EQUIVALENT DOSE IN 2 GY FRACTIONS - A SIMPLE APPLICATION OF THE LINEAR-QUADRATIC FORMULA [J].
BARTON, M .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1995, 31 (02) :371-378
[3]   CONTINUOUS POSTOPERATIVE EPIDURAL ANALGESIA FOR GYNECOLOGIC ONCOLOGY PATIENTS [J].
BLYTHE, JG ;
HODEL, KA ;
WAHL, TM ;
MILLER, RN ;
MAYFIELD, WR ;
SCHNEIDER, SL .
GYNECOLOGIC ONCOLOGY, 1990, 37 (03) :307-310
[4]   IMAGING IN GYNECOLOGIC MALIGNANCIES [J].
BRAGG, DG ;
HRICAK, H .
CANCER, 1993, 71 (04) :1648-1651
[5]   A COMPARATIVE-STUDY OF COMPUTERIZED-TOMOGRAPHY, MAGNETIC-RESONANCE-IMAGING, AND CLINICAL STAGING FOR THE DETECTION OF EARLY CERVIX CANCER [J].
BRODMAN, M ;
FRIEDMAN, F ;
DOTTINO, P ;
JANUS, C ;
PLAXE, S ;
COHEN, C .
GYNECOLOGIC ONCOLOGY, 1990, 36 (03) :409-412
[6]   MR APPEARANCE OF THE NORMAL AND ABNORMAL VAGINA AFTER HYSTERECTOMY [J].
BROWN, JJ ;
GUTIERREZ, ED ;
LEE, JKT .
AMERICAN JOURNAL OF ROENTGENOLOGY, 1992, 158 (01) :95-99
[7]   VAGINAL RECURRENCE OF ENDOMETRIAL CARCINOMA [J].
BROWN, JM ;
DOCKERTY, MB ;
SYMMONDS, RE ;
BANNER, EA .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1968, 100 (04) :544-&
[8]   Outcome of treatment of upper third vaginal recurrences of cervical and endometrial carcinomas with interstitial brachytherapy [J].
Charra, C ;
Roy, P ;
Coquard, R ;
Romestaing, P ;
Ardiet, JM ;
Gerard, JP .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1998, 40 (02) :421-426
[9]   IMPROVED TREATMENT PLANNING FOR THE SYED-NEBLETT TEMPLATE USING ENDORECTAL-COLI MAGNETIC-RESONANCE AND INTRAOPERATIVE (LAPAROTOMY LAPAROSCOPY) GUIDANCE - A NEW INTEGRATED TECHNIQUE FOR HYSTERECTOMIZED WOMEN WITH VAGINAL TUMORS [J].
CORN, BW ;
LANCIANO, RM ;
ROSENBLUM, N ;
SCHNALL, M ;
KING, S ;
EPPERSON, R .
GYNECOLOGIC ONCOLOGY, 1995, 56 (02) :255-261
[10]   Survival after relapse in patients with endometrial cancer:: results from a randomized trial [J].
Creutzberg, CL ;
van Putten, WLJ ;
Koper, PC ;
Lybeert, MLM ;
Jobsen, JJ ;
Wárlám-Rodenhuis, CC ;
De Winter, KAJ ;
Lutgens, LCHW ;
van den Bergh, ACM ;
van der Steen-Banasik, E ;
Beerman, H ;
van Lent, M .
GYNECOLOGIC ONCOLOGY, 2003, 89 (02) :201-209