Successful treatment of pulmonary metastases associated with advanced hepatocellular carcinoma by systemic 5-fluorouracil combined with interferon-α in a hemodialysis patient

被引：2

作者：

Katamura, Yoshio ^{[1
]}

Aikata, Hiroshi ^{[1
]}

Kimura, Yuki ^{[1
]}

Azakami, Takahiro ^{[1
]}

Kawaoka, Tomokazu ^{[1
]}

Takaki, Shintaro ^{[1
]}

Waki, Koji ^{[1
]}

Hiramatsu, Akira ^{[1
]}

Kawakami, Yoshiiku ^{[1
]}

Takahashi, Shoichi ^{[1
]}

Chayama, Kazuaki ^{[1
]}

机构：

[1] Hiroshima Univ, Dept Med & Mol Sci, Div Frontier Med Sci,Grad Sch Biomed Sci, Programs Biomed Res,Minami Ku, Hiroshima 7348551, Japan

来源：

HEPATOLOGY RESEARCH | 2009年 / 39卷 / 04期

关键词：

extrahepatic metastases; 5-fluorouracil; hemodialysis; hepatocellular carcinoma; interferon; pulmonary metastasis; systemic combination chemotherapy; ARTERIAL INFUSION CHEMOTHERAPY; PHASE-II TRIAL; COMBINATION THERAPY; INTRAARTERIAL; 5-FLUOROURACIL; CLINICAL-FEATURES; TUMOR THROMBOSIS; CISPLATIN; FLUOROURACIL; S-1; PROGRESSION;

D O I：

10.1111/j.1872-034X.2008.00448.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

A 54-year-old man maintained on hemodialysis had a relapse of multiple pulmonary metastases after multimodal therapy for primary hepatocellular carcinoma (HCC). He was treated with tegafur-uracil (UFT; 400 mg/day) and interferon alfa (IFN-alpha; 5 x 10(6) units three times per week) for 4 weeks. Following this he was treated with systemic 5-fluorouracil (5-FU; 1000 mg/day, 5 days per week) and cisplatin (CDDP; 10 mg/day, 5 days per week for 2 weeks). The response to the above treatments was inadequate; pulmonary metastasis deteriorated. Finally, we selected systemic chemotherapy of 5-FU (750 mg/day, 5 days per week) and recombinant IFN-alpha-2b (3 x 10(6) units three times per week) for 2 weeks. This therapy resulted in excellent shrinkage of pulmonary metastases, without severe adverse reactions. Hemodialysis was performed three times a week. We report a case of successful treatment of pulmonary metastases by systemic combination chemotherapy of 5-FU-IFN, previously unsuccessfully treated with UFT-IFN and 5-FU-CDDP in a patient on hemodialysis. Further studies are needed to select appropriate drugs with fluoropyrimidine-based systemic chemotherapy, and to analyze the pharmacokinetics of those agents in hemodialysis patients with HCC and extrahepatic metastases.

引用

页码：415 / 420

页数：6

共 39 条

[11] Advanced hepatocellular carcinoma with distant metastases, successfully treated by a combination therapy of α-interferon and oral tegafur/uracil [J].