Trials and tribulations on the path to developing a dengue vaccine

被引：27

作者：

Thomas, Stephen J. ^{[1
]}

Rothman, Alan L. ^{[2
]}

机构：

[1] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA

[2] Univ Rhode Isl, Providence, RI 02908 USA

来源：

VACCINE | 2015年 / 33卷

关键词：

Dengue; Vaccine; Immunology; HUMAN INFECTION MODEL; CLINICAL LABORATORY RESPONSES; NEUTRALIZING ANTIBODY-LEVELS; HEALTHY ADULT VOLUNTEERS; FLAVIVIRUS-NAIVE ADULTS; PRIMARY-SCHOOL CHILDREN; VIRUS-INFECTION; NONHUMAN-PRIMATES; HUMAN CHALLENGE; JAPANESE ENCEPHALITIS;

D O I：

10.1016/j.vaccine.2015.05.095

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dengue is a rapidly expanding global health problem. Development of a safe and efficacious tetravalent vaccine along with strategic application of vector control activities represents a promising approach to reducing the global disease burden. Although many vaccine development challenges exist, numerous candidates are in clinical development and one has been tested in three clinical endpoint studies. The results of these studies have raised numerous questions about how we measure vaccine immunogenicity and how these readouts are associated with clinical outcomes in vaccine recipients who experience natural infection. In this review the authors discuss the dengue vaccine pipeline, development challenges, the dengue vaccine-immunologic profiling intersection, and research gaps. (C) 2015 by American Journal of Preventive Medicine and Elsevier Ltd. All rights reserved.

引用

页码：D24 / D31

页数：8

共 135 条

[21] Can non-human primates serve as models for investigating dengue disease pathogenesis? [J].

Clark, Kristina B. ;

Onlamoon, Nattawat ;

Hsiao, Hui-Mien ;

Perng, Guey C. ;

Villinger, Francois .

FRONTIERS IN MICROBIOLOGY, 2013, 4

[22] FURTHER EXPERIMENTS IN THE ETIOLOGY OF DENGUE FEVER. [J].

Cleland, J. Burton ;

Bradley, Burton .

JOURNAL OF HYGIENE, 1919, 18 (03) :217-254

[23] Development of a recombinant tetravalent dengue virus vaccine: Innmunogenicity and efficacy studies in mice and monkeys [J].

Clements, David E. ;

Coller, Beth-Ann G. ;

Lieberman, Michael M. ;

Ogata, Steven ;

Wang, Gordon ;

Harada, Kent E. ;

Putnak, J. Robert ;

Ivy, John M. ;

McDonell, Michael ;

Bignami, Gary S. ;

Peters, Iain D. ;

Leung, Julia ;

Weeks-Levy, Carolyn ;

Nakano, Eileen T. ;

Humphreys, Tom .

VACCINE, 2010, 28 (15) :2705-2715

[24] The development of recombinant subunit envelope-based against dengue virus induced disease [J].

Coller, Beth-Ann G. ;

Clements, David E. ;

Bett, Andrew J. ;

Sagar, Sangeetha L. ;

Ter Meulen, Jan H. .

VACCINE, 2011, 29 (42) :7267-7275

[25] Identification of human neutralizing antibodies that bind to complex epitopes on dengue virions [J].

de Alwis, Ruklanthi ;

Smith, Scott A. ;

Olivarez, Nicholas P. ;

Messer, William B. ;

Huynh, Jeremy P. ;

Wahala, Wahala M. P. B. ;

White, Laura J. ;

Diamond, Michael S. ;

Baric, Ralph S. ;

Crowe, James E., Jr. ;

de Silva, Aravinda M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (19) :7439-7444

[26] The live attenuated dengue serotype 1 vaccine rDEN1Δ30 is safe and highly immunogenic in healthy adult volunteers [J].

Durbin, Anna P. ;

McArthur, Julie ;

Marron, Jennifer A. ;

Blaney, Joseph E., Jr. ;

Thumar, Bhavin ;

Wanionek, Kim ;

Murphy, Brian R. ;

Whitehead, Stephen S. .

HUMAN VACCINES, 2006, 2 (04) :167-173

[27] rDEN2/4Δ30(ME), a live attenuated chimeric dengue serotype 2 vaccine, is safe and highly immunogenic in healthy dengue-naive adults [J].

Durbin, Anna P. ;

McArthur, Julie H. ;

Marron, Jennifer A. ;

Blaney, Joseph E. ;

Thumar, Bhavin ;

Wanionek, Kimberli ;

Murphy, Brian R. ;

Whitehead, Stephen S. .

HUMAN VACCINES, 2006, 2 (06) :255-260

[28] A Single Dose of Any of Four Different Live Attenuated Tetravalent Dengue Vaccines Is Safe and Immunogenic in Flavivirus-naive Adults: A Randomized, Double-blind Clinical Trial [J].

Durbin, Anna P. ;

Kirkpatrick, Beth D. ;

Pierce, Kristen K. ;

Elwood, Daniel ;

Larsson, Catherine J. ;

Lindow, Janet C. ;

Tibery, Cecilia ;

Sabundayo, Beulah P. ;

Shaffer, Donna ;

Talaat, Kawsar R. ;

Hynes, Noreen A. ;

Wanionek, Kimberli ;

Carmolli, Marya P. ;

Luke, Catherine J. ;

Murphy, Brian R. ;

Subbarao, Kanta ;

Whitehead, Stephen S. .

JOURNAL OF INFECTIOUS DISEASES, 2013, 207 (06) :957-965

[29] Development and clinical evaluation of multiple investigational monovalent DENV vaccines to identify components for inclusion in a live attenuated tetravalent DENV vaccine [J].

Durbin, Anna P. ;

Kirkpatrick, Beth D. ;

Pierce, Kristen K. ;

Schmidt, Alexander C. ;

Whitehead, Stephen S. .

VACCINE, 2011, 29 (42) :7242-7250

[30] A Single Dose of the DENV-1 Candidate Vaccine rDEN1Δ30 Is Strongly Immunogenic and Induces Resistance to a Second Dose in a Randomized Trial [J].

Durbin, Anna P. ;

Whitehead, Stephen S. ;

Shaffer, Donna ;

Elwood, Dan ;

Wanionek, Kimberli ;

Thumar, Bhavin ;

Blaney, Joseph E. ;

Murphy, Brian R. ;

Schmidt, Alexander C. .

PLOS NEGLECTED TROPICAL DISEASES, 2011, 5 (08)

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