Trials and tribulations on the path to developing a dengue vaccine

被引：27

作者：

Thomas, Stephen J. ^{[1
]}

Rothman, Alan L. ^{[2
]}

机构：

[1] Walter Reed Army Inst Res, Silver Spring, MD 20910 USA

[2] Univ Rhode Isl, Providence, RI 02908 USA

来源：

VACCINE | 2015年 / 33卷

关键词：

Dengue; Vaccine; Immunology; HUMAN INFECTION MODEL; CLINICAL LABORATORY RESPONSES; NEUTRALIZING ANTIBODY-LEVELS; HEALTHY ADULT VOLUNTEERS; FLAVIVIRUS-NAIVE ADULTS; PRIMARY-SCHOOL CHILDREN; VIRUS-INFECTION; NONHUMAN-PRIMATES; HUMAN CHALLENGE; JAPANESE ENCEPHALITIS;

D O I：

10.1016/j.vaccine.2015.05.095

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Dengue is a rapidly expanding global health problem. Development of a safe and efficacious tetravalent vaccine along with strategic application of vector control activities represents a promising approach to reducing the global disease burden. Although many vaccine development challenges exist, numerous candidates are in clinical development and one has been tested in three clinical endpoint studies. The results of these studies have raised numerous questions about how we measure vaccine immunogenicity and how these readouts are associated with clinical outcomes in vaccine recipients who experience natural infection. In this review the authors discuss the dengue vaccine pipeline, development challenges, the dengue vaccine-immunologic profiling intersection, and research gaps. (C) 2015 by American Journal of Preventive Medicine and Elsevier Ltd. All rights reserved.

引用

页码：D24 / D31

页数：8

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