Synthesis of spiroacetal-nucleosides as privileged natural product-like scaffolds

被引：14
|
作者：
Choi, Ka Wai [1 ]
Brimble, Margaret A. [1 ]
机构：
[1] Univ Auckland, Dept Chem, Auckland, New Zealand
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2009年 / 7卷 / 07期
关键词：
PROTEIN PHOSPHATASE INHIBITOR; (+)-SPIROLAXINE METHYL-ETHER; PYLORI AGENTS CJ-12,954; SPONGISTATIN; STEREOCONTROLLED SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; ABSOLUTE-CONFIGURATION; FACILE SYNTHESIS; BUILDING-BLOCKS; OKADAIC ACID;
D O I：
10.1039/b818314g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The elaboration of a 6,6-spiroacetal scaffold to incorporate a nucleoside unit at the anomeric position is described. The novel spiroacetal-nucleoside hybrids 11 were generated via nucleosidation of cetoxy-spiroacetal 10 with a series of silylated nucleobases under Vorbruggen conditions.
引用
收藏
页码：1424 / 1436
页数：13
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