Synthesis of spiroacetal-nucleosides as privileged natural product-like scaffolds

被引：14

作者：

Choi, Ka Wai ^{[1
]}

Brimble, Margaret A. ^{[1
]}

机构：

[1] Univ Auckland, Dept Chem, Auckland, New Zealand

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2009年 / 7卷 / 07期

关键词：

PROTEIN PHOSPHATASE INHIBITOR; (+)-SPIROLAXINE METHYL-ETHER; PYLORI AGENTS CJ-12,954; SPONGISTATIN; STEREOCONTROLLED SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; ABSOLUTE-CONFIGURATION; FACILE SYNTHESIS; BUILDING-BLOCKS; OKADAIC ACID;

D O I：

10.1039/b818314g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The elaboration of a 6,6-spiroacetal scaffold to incorporate a nucleoside unit at the anomeric position is described. The novel spiroacetal-nucleoside hybrids 11 were generated via nucleosidation of cetoxy-spiroacetal 10 with a series of silylated nucleobases under Vorbruggen conditions.

引用

页码：1424 / 1436

页数：13

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