Systemic Effects of TRAIL (TNF-Related Apoptosis-Inducing Ligand) during Acute γ-Irradiation

被引：0
|
作者：
Arkhipova, E. N. [1 ]
Alchinova, I. B. [1 ]
Cherepov, A. B. [2 ]
Rozanov, D. V. [3 ]
Medvedeva, Yu. S. [1 ]
Karganov, M. Yu. [1 ]
机构：
[1] Russian Acad Med Sci, Res Inst Gen Pathol & Pathophysiol, Moscow 109801, Russia
[2] Russian Acad Med Sci, PK Anokhin Normal Physiol Res Inst, Moscow, Russia
[3] Oregon Hlth & Sci Univ, Portland, OR 97201 USA
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2014年 / 156卷 / 04期
基金：
俄罗斯基础研究基金会;
关键词：
radioresistance; TRAIL; apoptosis; mice;
D O I：
10.1007/s10517-014-2372-9
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The effects of TRAIL at various physiological levels were studied on 101/Hf and C3H/Sn mice during acute gamma-irradiation with 750 R. An intravenous injection of TRAIL attenuated the effects of gamma-irradiation on the body weight, subfractions of blood plasma, horizontal and vertical activity in the open-field test, tissue injury in the small intestine and liver, and content of Hassall's corpuscles in the thymus. The degree of these changes differed in mice of study strains.
引用
收藏
页码：452 / 456
页数：5
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